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Literature summary for 1.1.1.34 extracted from

  • Gueguen, Y.; Ferrari, L.; Souidi, M.; Batt, A.M.; Lutton, C.; Siest, G.; Visvikis, S.
    Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase (2007), Basic Clin. Pharmacol. Toxicol., 100, 392-397.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information 27-hydroxycholesterol strongly supresses the expression of HMGR, the in vivo inhibition of sterol 27-hydroxylase CYP27A1, e.g. by the drugs rapamycin and cyclosporine A, reduces the inhibition and thus increases HMGR activity, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methyl-glutaryl CoA reductase
-
Homo sapiens
HMG-CoA reductase
-
Homo sapiens
HMGR
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens