Any feedback?
Literature summary for 1.1.1.34 extracted from
- HMG-CoA reductase is regulated by salinity at the level of transcription in Haloferax volcanii (2006), Extremophiles, 11, 49-55.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene hmgR, expression analysis under different salinity growth conditions, hmgR transcript increases in abundance with increasing salinity by a factor of 2.2fold | Haloferax volcanii |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Haloferax volcanii | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
x * 46000, SDS-PAGE | Haloferax volcanii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Haloferax volcanii | HMGR is a key enzyme in the mevalonate pathway of isoprenoid biosynthesis, the sole route in haloarchaea for lipid and carotenoid production | (R)-mevalonate + 2 NADP+ + CoA | - |
? |  |
| additional information | Haloferax volcanii | HMG-CoA reductase is regulated by salinity at the level of transcription | ? | - |
? | |
| additional information | Haloferax volcanii | the expression of HMGR is regulated in response to non-optimal salinity in the halophilic archaeon | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haloferax volcanii | - |
- |
- |
| Haloferax volcanii | - |
gene hmgR | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | growth at high and low salinity, quantitative expression analysis, overview, the expression of HMGR is regulated in response to non-optimal salinity in the halophilic archaeon | Haloferax volcanii | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.69 | - |
native enzyme in cell extract soluble fraction | Haloferax volcanii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Haloferax volcanii | (R)-mevalonate + 2 NADP+ + CoA | - |
? | |
| (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | HMGR is a key enzyme in the mevalonate pathway of isoprenoid biosynthesis, the sole route in haloarchaea for lipid and carotenoid production | Haloferax volcanii | (R)-mevalonate + 2 NADP+ + CoA | - |
? | |
| additional information | HMG-CoA reductase is regulated by salinity at the level of transcription | Haloferax volcanii | ? | - |
? | |
| additional information | the expression of HMGR is regulated in response to non-optimal salinity in the halophilic archaeon | Haloferax volcanii | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 46000, SDS-PAGE | Haloferax volcanii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HMG-CoA reductase | - |
Haloferax volcanii |
| HMGR | - |
Haloferax volcanii |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Haloferax volcanii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Haloferax volcanii | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
