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Literature summary for 1.1.1.34 extracted from

  • Mokashi, V.; Singh, D.K.; Porter, T.D.
    Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro (2005), Arch. Biochem. Biophys., 433, 474-480.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
supernatant protein factor i.e. SPF, a 46 kDa cytosolic protein, stimulation of squalene monooxygenase and cholesterol biosynthesis in hepatoma cell culture, acts directly on the enzyme, not by increasing the enzyme amount Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Rattus norvegicus rate-limiting step of cholesterol biosynthesis mevalonolactone + CoA + 2 NADP+ + H2O
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
McA-RH7777 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Rattus norvegicus mevalonolactone + CoA + 2 NADP+ + H2O
-
r
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ rate-limiting step of cholesterol biosynthesis Rattus norvegicus mevalonolactone + CoA + 2 NADP+ + H2O
-
r

Synonyms

Synonyms Comment Organism
HMG-CoA reductase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus