Activating Compound | Comment | Organism | Structure |
---|---|---|---|
supernatant protein factor | i.e. SPF, a 46 kDa cytosolic protein, stimulation of squalene monooxygenase and cholesterol biosynthesis in hepatoma cell culture, acts directly on the enzyme, not by increasing the enzyme amount | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Rattus norvegicus | rate-limiting step of cholesterol biosynthesis | mevalonolactone + CoA + 2 NADP+ + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
McA-RH7777 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Rattus norvegicus | mevalonolactone + CoA + 2 NADP+ + H2O | - |
r | |
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | rate-limiting step of cholesterol biosynthesis | Rattus norvegicus | mevalonolactone + CoA + 2 NADP+ + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
HMG-CoA reductase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |