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Literature summary for 1.1.1.333 extracted from

  • Trefzer, C.; Skovierova, H.; Buroni, S.; Bobovska, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M.; Makarov, V.; Cole, S.; Riccardi, G.; Mikusova, K.; Johnsson, K.
    Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1 (2012), J. Am. Chem. Soc., 134, 912-915.
    View publication on PubMed
Search for more literature for 1.1.1.333

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycolicibacterium smegmatis

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R610
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase is constituted of decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1 and decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase DprE2 that together catalyze the epimerization of decaprenylphosphoryl-beta-D-ribofuranose to decaprenylphosphoryl-beta-D-arabinofuranose Mycolicibacterium smegmatis ?
-
 ?
trans,octacis-decaprenylphospho-beta-D-erythro-pentafuranosid-2-ulose + NADH reaction catalyzed by decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase DprE2 Mycolicibacterium smegmatis trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+
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 ?

Synonyms

Synonyms Comment Organism
DprE2
-
 Mycolicibacterium smegmatis
MSMEG_6385
-
 Mycolicibacterium smegmatis

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mycolicibacterium smegmatis

General Information

General Information Comment Organism
physiological function decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase is constituted of DprE1 and DprE2 that together catalyze the epimerization of decaprenylphosphoryl-beta-D-ribofuranose to decaprenylphosphoryl-beta-D-arabinofuranose Mycolicibacterium smegmatis