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Literature summary for 1.1.1.315 extracted from

  • Simon, A.; Hellman, U.; Wernstedt, C.; Eriksson, U.
    The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases (1995), J. Biol. Chem., 270, 1107-1112.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Cos-1 cells Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated to membrane, and ssequence displays several potential membrane-spanning segments Bos taurus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
x * 32000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus Q27979 sequence similarities to short chain alcohol dehydrogenases
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification N-terminal 18 amino acids of sequence have the characteristics of a classigal signal sequence Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelium specific expression Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-cis-retinol + NAD+
-
Bos taurus 11-cis-retinal + NADH + H+
-
?

Subunits

Subunits Comment Organism
? x * 32000, SDS-PAGE Bos taurus
More enzyme associates with p63, an abundant membrane protein in retinal pigment epithelium Bos taurus

Cofactor

Cofactor Comment Organism Structure
additional information no cofactor: NADP+ Bos taurus
NAD+
-
Bos taurus