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Literature summary for extracted from

  • Simon, A.; Hellman, U.; Wernstedt, C.; Eriksson, U.
    The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases (1995), J. Biol. Chem., 270, 1107-1112.
    View publication on PubMed


Cloned (Comment) Organism
expression in Cos-1 cells Bos taurus


Localization Comment Organism GeneOntology No. Textmining
membrane associated to membrane, and ssequence displays several potential membrane-spanning segments Bos taurus 16020

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
x * 32000, SDS-PAGE Bos taurus


Organism UniProt Comment Textmining
Bos taurus Q27979 sequence similarities to short chain alcohol dehydrogenases

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification N-terminal 18 amino acids of sequence have the characteristics of a classigal signal sequence Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelium specific expression Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-cis-retinol + NAD+
Bos taurus 11-cis-retinal + NADH + H+


Subunits Comment Organism
? x * 32000, SDS-PAGE Bos taurus
More enzyme associates with p63, an abundant membrane protein in retinal pigment epithelium Bos taurus


Cofactor Comment Organism Structure
additional information no cofactor: NADP+ Bos taurus
Bos taurus