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Literature summary for 1.1.1.313 extracted from

  • Zhou, Y.; Wei, Y.; Nanjaraj Urs, A.N.; Lin, L.; Xu, T.; Hu, Y.; Ang, E.L.; Zhao, H.; Yuchi, Z.; Zhang, Y.
    Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense (2019), Biosci. Rep., 39, BSR20190715.
    View publication on PubMed
Search for more literature for 1.1.1.313

Cloned(Commentary)

Cloned (Comment) Organism
gene isfD, genetic structure Chromohalobacter israelensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter israelensis
-
 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter israelensis DSM 3043
-
 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter israelensis ATCC BAA-138
-
 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter israelensis CIP 106854
-
 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter israelensis NCIMB 13768
-
 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter israelensis 1H11
-
 isethionate + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Chromohalobacter israelensis Q1R183
-
-
Chromohalobacter israelensis 1H11 Q1R183
-
-
Chromohalobacter israelensis ATCC BAA-138 Q1R183
-
-
Chromohalobacter israelensis CIP 106854 Q1R183
-
-
Chromohalobacter israelensis DSM 3043 Q1R183
-
-
Chromohalobacter israelensis NCIMB 13768 Q1R183
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-sulfoacetaldehyde + NADPH + H+
-
 Chromohalobacter israelensis isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+
-
 Chromohalobacter israelensis DSM 3043 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+
-
 Chromohalobacter israelensis ATCC BAA-138 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+
-
 Chromohalobacter israelensis CIP 106854 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+
-
 Chromohalobacter israelensis NCIMB 13768 isethionate + NADP+
-
 r
2-sulfoacetaldehyde + NADPH + H+
-
 Chromohalobacter israelensis 1H11 isethionate + NADP+
-
 r

Synonyms

Synonyms Comment Organism
IsfD
-
 Chromohalobacter israelensis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Chromohalobacter israelensis
NADPH
-
 Chromohalobacter israelensis

General Information

General Information Comment Organism
evolution the enzyme sulfoacetaldehyde reductase IsfD belongs to the short-chain dehydrogenase/reductase (SDR) family Chromohalobacter israelensis
metabolism in the pathway, taurine is imported by a taurine ABC transporter (TauABC), and converted into sulfoacetaldehyde by taurine:oxoglutarate aminotransferase (Toa), generating glutamate as an intermediate for nitrogen metabolism. The NADPH-dependent sulfoacetaldehyde reductase (IsfD), belonging to the SDR family, generates isethionate as a waste produce, which is exported by the putative isethionate exporter (IsfE) Chromohalobacter israelensis
physiological function hydroxyethylsulfonate (isethionate (Ise)) is generated by the sulfoacetaldehyde reductases from human gut bacteria. Isethionate is thought to be derived from aminoethylsulfonate (taurine), as a byproduct of taurine nitrogen assimilation by certain anaerobic bacteria inhabiting the taurine-rich mammalian gut Chromohalobacter israelensis