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Literature summary for 1.1.1.302 extracted from

  • Graupner, M.; Xu, H.; White, R.H.
    The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin (2002), J. Bacteriol., 184, 1952-1957.
    View publication on PubMed
Search for more literature for 1.1.1.302

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Escherichia coli Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ Methanosarcina thermophila step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ Methanosarcina thermophila step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ Methanocaldococcus jannaschii step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ Methanocaldococcus jannaschii step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii
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-
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Methanosarcina thermophila
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanosarcina thermophila 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanosarcina thermophila 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ NADPH and NADH function equally well as reductant Methanosarcina thermophila 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
additional information the enzyme does not catalyze the pyrimidine nucleotide-dependent reduction of 5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate Methanocaldococcus jannaschii ?
-
 ?

Synonyms

Synonyms Comment Organism
MJ0671
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 Methanocaldococcus jannaschii
MJ0671 pyrimidine reductase
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 Methanocaldococcus jannaschii

Cofactor

Cofactor Comment Organism Structure
NADH NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii
NADH NADPH and NADH function equally well as reductant Methanosarcina thermophila
NADPH NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii
NADPH NADPH and NADH function equally well as reductant Methanosarcina thermophila