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Literature summary for 1.1.1.300 extracted from

  • Tian, J.; Liu, J.; Li, J.; Zheng, J.; Chen, L.; Wang, Y.; Liu, Q.; Ni, J.
    The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism (2018), Nutr. Metab., 15, 7 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene rdh11, co-expression of GFP-tagged or EYFP-tagged RDH11 with HA-tagged selenoprotein F in HEK-293T cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
selenoprotein F SELENOF, cloned from a human fetal brain cDNA library, interacts with RDH11 and blocks its enzyme activity to reduce all-trans-retinaldehyde. The reductase activity of RDH11 affected by selenoprotein F Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum co-localization of RDH11 and selenoprotein F Homo sapiens 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinal + NADPH + H+ Homo sapiens
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all-trans-retinol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TC12
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
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eye RDH11 is involved in the retinal pigment epithelium (RPE) during the retinoid visual cycle Homo sapiens
-
prostate gland
-
Homo sapiens
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retinal pigment epithelium
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Homo sapiens
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testis
-
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinal + NADPH + H+
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Homo sapiens all-trans-retinol + NADP+
-
?
additional information RDH11 is able to reduce both all-trans- and cis-retinaldehydes into all-trans- and -cis-retinol (Vitamin A) Homo sapiens ?
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-

Synonyms

Synonyms Comment Organism
RDH11
-
Homo sapiens
retinol dehydrogenase 11
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
evolution human retinol dehydrogenase 11 RDH11 belongs to the short-chain dehydrogenases/ reductases (SDR) family Homo sapiens
metabolism interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implying a role of selenoprotein F in vitamin A metabolism. Selenoprotein F has been reported to play important roles in oxidative stress, endoplasmic reticulum (ER) stress, and carcinogenesis. Both of selenoprotein F and RDH11 might reduce all-trans-retinaldehyde into all-trans-retinol, but overexpressed selenoprotein F and RDH11 inhibit the enzyme activity of each other Homo sapiens
physiological function RDH11 is an enzyme for the reduction of all-trans-retinaldehyde to all-trans-retinol (vitamin A). It is involved in the retinal pigment epithelium (RPE) during the retinoid visual cycle. Interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) is analyzed by yeast two-hybrid system and determination of production of retinol. The production of retinol is decreased by SELENOF overexpression, resulting in more retinaldehyde Homo sapiens