Application | Comment | Organism |
---|---|---|
drug development | the enzyme might be a good target for anti-fungal drug development | Candida albicans |
additional information | HOM6 deletion reduces Candida albicans cell adhesion to polystyrene, which is a common plastic used in many medical devices | Candida albicans |
Cloned (Comment) | Organism |
---|---|
gene HOM6, DNA and amino acid sequence determination and analysis from the strain SC5314 genome, sequence comparison, reintegration of the gene encoding the wild-type enzyme into HOM6-deletion strains | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of HOM6-deleted (HOM6/hom6DELT and hom6DELTA/hom6DELTA) and HOM6-reintegrated (hom6DELTA/hom6DELTA::HOM6 and hom6DELTA::HOM6/hom6DELTA::HOM6) strains | Candida albicans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell wall | - |
Candida albicans | 5618 | - |
cytosol | - |
Candida albicans | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homoserine + NADP+ | Candida albicans | - |
L-aspartate 4-semialdehyde + NADPH + H+ | - |
r | |
L-homoserine + NADP+ | Candida albicans SC5314 / ATCC MYA-2876 | - |
L-aspartate 4-semialdehyde + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | Q5AIA2 | - |
- |
Candida albicans SC5314 / ATCC MYA-2876 | Q5AIA2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homoserine + NADP+ | - |
Candida albicans | L-aspartate 4-semialdehyde + NADPH + H+ | - |
r | |
L-homoserine + NADP+ | - |
Candida albicans SC5314 / ATCC MYA-2876 | L-aspartate 4-semialdehyde + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
Hom6 | - |
Candida albicans |
orf19.2951 | - |
Candida albicans |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Candida albicans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
assay at | Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Candida albicans | |
NADPH | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
malfunction | HOM6 deletions cause translational arrest in cells grown under amino acid starvation conditions. HOM6 deletion reduces Candida albicans cell adhesion to polystyrene, which is a common plastic used in many medical devices. HOM6-homozygous mutants are hypersensitive to hygromycin B and cycloheximide as compared with wild-type, HOM6-heterozygous, and HOM6-reintegrated strains. HOM6 deletion affects translation and leads to the accumulation of free ribosomes | Candida albicans |
metabolism | homoserine dehydrogenase activity and is involved in the biosynthesis of methionine and threonine | Candida albicans |