Literature summary for 1.1.1.3 extracted from

Jacques, S.L.; Nieman, C.; Bareich, D.; Broadhead, G.; Kinach, R.; Honek, J.F.; Wright, G.D.
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity (2001), Biochim. Biophys. Acta, 1544, 28-41.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in Escherichia coli	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
H309A	decrease of catalytic activity and elimination of substrate inhibition	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P31116	-	-

Purification (Commentary)

Purification (Comment)	Organism
overexpressed in Escherichia coli	Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
23.7	-	-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-aspartate 4-semialdehyde + NAD(P)H	-	Saccharomyces cerevisiae	L-homoserine + NAD(P)+	-	?
L-homoserine + NAD(P)+	-	Saccharomyces cerevisiae	L-aspartate 4-semialdehyde + NAD(P)H	-	r

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Release 2023.1 (January 2023)