Literature summary for 1.1.1.284 extracted from

Barnett, S.D.; Smith, C.R.; Ulrich, C.C.; Baker, J.E.; Buxton, I.L.O.
S-Nitrosoglutathione reductase underlies the dysfunctional relaxation to nitric oxide in preterm labor (2018), Sci. Rep., 8, 5614 .

Search for more literature for 1.1.1.284

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(5-(4-(1H-imidazol-1-yl) phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl) propionic acid	N6022, a commercial potent and specific inhibitor of GSNOR	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-nitrosoglutathione + NADH + H+	Homo sapiens	-	GSSG + ammonia + NAD+	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11766	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
smooth muscle	-	Homo sapiens	-
uterus	preterm and term myometrium	Homo sapiens	-
vascular smooth muscle	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-nitrosoglutathione + NADH + H+	-	Homo sapiens	GSSG + ammonia + NAD+	-	ir

Synonyms

Synonyms	Comment	Organism
ADH5	-	Homo sapiens
GSNOR	-	Homo sapiens
S-nitrosoglutathione reductase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	increased expression of the reductase in preterm myometrium is associated with decreased total protein S-nitrosation. Global protein S-nitrosation is also diminished in spontaneously in labor preterm (sPTL). Blockade of S-nitrosoglutathione reductase relaxes sPTL tissue. Addition of NO donor to the actin motility assay attenuates force. Failure of soluble guanylyl cyclase (sGC) activation to mediate relaxation in sPTL tissues, together with the ability of NO to relax labor at term (TL), but not sPTL myometrium, suggests a unique pathway for NO-mediated relaxation in myometrium. Blockade of GSNOR activity relaxes term non-laboring (TNL) myometrium. GSNOR inhibition affects force, and force reduction may be consistent with S-nitrosations lowering the threshold for contractions until term	Homo sapiens
physiological function	S-nitrosoglutathione (GSNO) reductase (GSNOR) is the enzymatic regulator of endogenous S-nitrosoglutathione availability. GSNO alters actin-myosin motility. Effect of GSNO on protein S-nitrosation in human myometrium, overview	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)