Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-chloro-3-(2-[4-ethoxyphenyl) (ethyl) amino]-2-oxoethyl)-1H-indole-2-carboxylic acid | C2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-nitrosoglutathione + NADH + H+ | Rattus norvegicus | - |
GSSG + ammonia + NAD+ | - |
ir | |
S-nitrosoglutathione + NADH + H+ | Rattus norvegicus Sprague Dawley | - |
GSSG + ammonia + NAD+ | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q7TQ90 | multienzyme complex | - |
Rattus norvegicus Sprague Dawley | Q7TQ90 | multienzyme complex | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac muscle fiber | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-nitrosoglutathione + NADH + H+ | - |
Rattus norvegicus | GSSG + ammonia + NAD+ | - |
ir | |
S-nitrosoglutathione + NADH + H+ | - |
Rattus norvegicus Sprague Dawley | GSSG + ammonia + NAD+ | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
ADH4 | - |
Rattus norvegicus |
alcohol dehydrogenase 5 | UniProt | Rattus norvegicus |
GSNOR | - |
Rattus norvegicus |
S-nitrosoglutathione reductase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus | |
NADH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | pharmacological inhibition of S-nitrosoglutathione reductase reduces cardiac damage induced by ischemia-reperfusion | Rattus norvegicus |
physiological function | S-nitrosoglutathione reductase (GSNOR) is an enzyme involved in the metabolism of S-nitrosothiols by producing denitrosylation, thus limiting the cardioprotective effect of NO. Cardioprotective effects of nitric oxide (NO) have been described through S-nitrosylation of several important proteins in the mitochondria of the cardiomyocyte. GSNOR plays a role in normal cardiac function, affecting vascular tone and cardiac contractility | Rattus norvegicus |