BRENDA - Enzyme Database show
show all sequences of 1.1.1.284

Bi-enzyme biosensor based on NAD+- and glutathione-dependent recombinant formaldehyde dehydrogenase and diaphorase for formaldehyde assay

Nikitina, O.; Shleev, S.; Gayda, G.; Demkiv, O.; Gonchar, M.; Gorton, L.; Csoeregi, E.; Nistor, M.; Sens. Actuators B Chem. B125, 1-9 (2007)
No PubMed abstract available

Data extracted from this reference:

Application
Application
Commentary
Organism
analysis
usage of the enzyme in a bi-enzyme biosensor based on NAD+- and glutathione-dependent recombinant formaldehyde dehydrogenase activity and diaphorase activity for a formaldehyde assay, overview
Ogataea angusta
Engineering
Amino acid exchange
Commentary
Organism
additional information
construction of a bi-enzyme biosensor based on NAD+- and glutathione-dependent recombinant genetically-engineered methylotrophic yeast formaldehyde dehydrogenase activity and from Bacillus stearothermophilus diaphorase activity as bio-recognition elements for a formaldehyde assay, overview, the sensor architecture comprises a first layer containing diaphorase cross-linked with an osmium complex-modified redox polymer (poly(vinylpyridine)-[osmium-(N,N'-methylated-2,2'-biimidalzole)3]3+/2+ complex) and a second layer formed by additional cross-linking of FDH with poly(ethylene glycol)(400)diglycidyl ether on the top, optimization, overview
Ogataea angusta
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
formaldehyde + glutathione + NAD+
Ogataea angusta
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
S-formylglutathione + NADH + H+
-
-
?
formaldehyde + glutathione + NAD+
Ogataea angusta Tf 11-6
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
S-formylglutathione + NADH + H+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Ogataea angusta
-
genetically-engineered methylotrophic yeast
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
formaldehyde + glutathione + NAD+
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
690067
Ogataea angusta
S-formylglutathione + NADH + H+
-
-
-
?
formaldehyde + glutathione + NAD+
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
690067
Ogataea angusta Tf 11-6
S-formylglutathione + NADH + H+
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Ogataea angusta
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Ogataea angusta
Application (protein specific)
Application
Commentary
Organism
analysis
usage of the enzyme in a bi-enzyme biosensor based on NAD+- and glutathione-dependent recombinant formaldehyde dehydrogenase activity and diaphorase activity for a formaldehyde assay, overview
Ogataea angusta
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
construction of a bi-enzyme biosensor based on NAD+- and glutathione-dependent recombinant genetically-engineered methylotrophic yeast formaldehyde dehydrogenase activity and from Bacillus stearothermophilus diaphorase activity as bio-recognition elements for a formaldehyde assay, overview, the sensor architecture comprises a first layer containing diaphorase cross-linked with an osmium complex-modified redox polymer (poly(vinylpyridine)-[osmium-(N,N'-methylated-2,2'-biimidalzole)3]3+/2+ complex) and a second layer formed by additional cross-linking of FDH with poly(ethylene glycol)(400)diglycidyl ether on the top, optimization, overview
Ogataea angusta
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
formaldehyde + glutathione + NAD+
Ogataea angusta
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
S-formylglutathione + NADH + H+
-
-
?
formaldehyde + glutathione + NAD+
Ogataea angusta Tf 11-6
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
S-formylglutathione + NADH + H+
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
formaldehyde + glutathione + NAD+
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
690067
Ogataea angusta
S-formylglutathione + NADH + H+
-
-
-
?
formaldehyde + glutathione + NAD+
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione
690067
Ogataea angusta Tf 11-6
S-formylglutathione + NADH + H+
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Ogataea angusta
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Ogataea angusta
Other publictions for EC 1.1.1.284
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Patra
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Cloning and characterization o ...
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739945
Oka
Isolation, sequencing, and het ...
Byssochlamys spectabilis, Byssochlamys spectabilis NBRC 109023
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741232
Zhang
An S-(hydroxymethyl)glutathion ...
Magnaporthe oryzae, Magnaporthe oryzae ATCC MYA-4617
PLoS ONE
10
e0120627
2015
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740432
Justino
FrxA is an S-nitrosoglutathion ...
Helicobacter pylori
FEBS J.
281
4495-4505
2014
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740547
Ken
Modulation of nitrosative stre ...
Taiwanofungus camphoratus
Int. J. Mol. Sci.
15
14166-14179
2014
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741216
Kubienova
Effect of abiotic stress stimu ...
Cucumis sativus, Pisum sativum
Planta
239
139-146
2014
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742700
Ken
Modulation of nitrosative str ...
Taiwanofungus camphoratus
Int. J. Mol. Sci.
15
14166-14179
2014
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723896
Barroso
-
Immunolocalization of S-nitros ...
Pisum sativum
Acta Physiol. Plant.
35
2635-2640
2013
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724453
Frungillo
Modulation of mitochondrial ac ...
Arabidopsis thaliana, Arabidopsis thaliana Columbia
Biochim. Biophys. Acta
1827
239-247
2013
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724489
Kubienova
Structural and functional char ...
Solanum lycopersicum, Solanum lycopersicum Amateur
Biochimie
95
889-902
2013
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3
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726395
Gomes
S-nitrosoglutathione reductase ...
Mus musculus
Proc. Natl. Acad. Sci. USA
110
2834-2839
2013
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725072
Galbis-Estrada
Glutathione-dependent formalde ...
Rattus norvegicus, Rattus norvegicus Wistar
Free Radic. Res.
46
77-84
2012
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725627
Wuensche
S-Nitrosoglutathione reductase ...
Nicotiana attenuata
J. Exp. Bot.
62
4605-4616
2011
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726053
Hou
Nitric oxide metabolism contro ...
Drosophila melanogaster
Nitric Oxide
24
17-24
2011
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726134
Tada
-
Glutathione-dependent formalde ...
Epipremnum aureum
Plant Biotechnol.
28
373-378
2011
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726241
Leterrier
Function of S-nitrosoglutathio ...
Arabidopsis thaliana, Helianthus annuus, Helianthus annuus X55
Plant Signal. Behav.
6
789-793
2011
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701643
Que
S-nitrosoglutathione reductase ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
180
226-231
2009
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703110
Chen
The Arabidopsis PARAQUAT RESIS ...
Arabidopsis sp.
Cell Res.
19
1377-1387
2009
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703165
Staab
Medium-chain fatty acids and g ...
Homo sapiens
Chem. Biol. Interact.
180
113-118
2009
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703794
Huang
-
An enzyme possessing both glut ...
Taiwanofungus camphoratus
Food Chem.
112
795-802
2009
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A novel nitroreductase of Stap ...
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Kinetic and cellular character ...
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690106
Achmann
Direct detection of formaldehy ...
Hyphomicrobium zavarzinii, Hyphomicrobium zavarzinii ZV 580
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696092
Staab
Reduction of S-nitrosoglutathi ...
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697214
Staab
Medium- and short-chain dehydr ...
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Human carbonyl reductase 1 is ...
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705522
Corpas
Localization of S-nitrosothiol ...
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706210
Lee
Modulation of nitrosative stre ...
Arabidopsis thaliana
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Ben Ali
Formaldehyde-sensitive sensor ...
Ogataea angusta, Ogataea angusta Tf-11-6
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2007
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686818
Demkiv
Formaldehyde dehydrogenase fro ...
Ogataea angusta, Ogataea angusta NCYC 495
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2007
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1
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Kidd
Glutathione-dependent alcohol ...
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Infect. Immun.
75
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2007
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689316
Jelski
The activity of class I, II, I ...
Homo sapiens
Pancreas
35
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2007
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690067
Nikitina
-
Bi-enzyme biosensor based on N ...
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B125
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Sanghani
Structure-function relationshi ...
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2006
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Godoy
S-Nitrosogluthathione reductas ...
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117-124
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Martinez
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Glutathione-dependent formalde ...
Arabidopsis thaliana
NATO Sci. Ser. Ser. I
371
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2006
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Espunya
Modification of intracellular ...
Arabidopsis thaliana
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Norin
Class III alcohol dehydrogenas ...
Agaricus bisporus
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559
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657422
Nakagawa
Molecular characterization of ...
Ogataea methanolica
Yeast
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Sanghani
Structure-function relationshi ...
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Achkor
Enhanced formaldehyde detoxifi ...
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1
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Sanghani
Human glutathione-dependent fo ...
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654632
Sanghani
Human glutathione-dependent fo ...
Homo sapiens
Biochemistry
41
15189-15194
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Arabidopsis glutathione-depend ...
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Lee
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657412
Baerends
Molecular characterization of ...
Ogataea angusta
Yeast
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37-42
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Sanghani
Kinetic mechanism of human glu ...
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Maize glutathione-dependent fo ...
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A double residue substitution ...
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1
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1
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3
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3
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1
1
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1
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3
-
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-
2
-
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-
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-
287896
Svensson
Structural and functional dive ...
Oryctolagus cuniculus
Eur. J. Biochem.
251
236-243
1998
-
-
1
-
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1
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1
1
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1
-
-
1
-
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-
-
-
287861
Yang
Structure of human chi chi alc ...
Homo sapiens
J. Mol. Biol.
265
330-343
1997
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-
-
1
-
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-
1
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1
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1
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1
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1
-
-
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-
-
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-
-
-
287880
Fernandez
Formaldehyde dehydrogenase fro ...
Arabidopsis thaliana, Drosophila melanogaster, Escherichia coli, Homo sapiens, Pisum sativum, Rattus norvegicus, Saccharomyces cerevisiae
Adv. Exp. Med. Biol.
414
373-381
1997
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-
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8
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4
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7
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17
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6
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7
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7
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8
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4
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-
17
-
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-
6
-
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-
-
-
-
-
-
-
-
287898
Gutheil
Induction of glutathione-depen ...
Escherichia coli, Haemophilus influenzae
Biochem. Biophys. Res. Commun.
238
693-696
1997
-
-
-
-
-
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2
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4
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4
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2
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2
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-
4
-
-
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-
-
-
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-
-
-
-
287860
Foglio
Characterization of the functi ...
Mus musculus
Eur. J. Biochem.
237
496-504
1996
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
-
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-
287892
Barber
Characterization of a glutathi ...
Rhodobacter sphaeroides
J. Bacteriol.
178
1386-1393
1996
-
-
-
-
-
-
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1
-
1
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1
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5
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1
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5
-
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-
287863
Estonius
Residues specific for class II ...
Homo sapiens
Biochemistry
33
15080-15085
1994
-
-
1
-
4
-
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1
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1
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1
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1
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1
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1
1
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4
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1
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1
-
1
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-
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-
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-
-
287887
Van Ophem
-
NAD- and co-substrate (GSH or ...
Candida boidinii, Ogataea angusta, Paracoccus denitrificans, Paracoccus versutus
FEMS Microbiol. Lett.
116
87-93
1994
-
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4
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4
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8
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4
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4
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4
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8
-
-
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-
4
-
-
-
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-
-
-
-
287895
Luque
Structure of the Drosophila me ...
Drosophila melanogaster
Eur. J. Biochem.
225
985-993
1994
-
-
1
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1
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1
1
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1
-
-
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-
-
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-
-
-
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-
-
-
-
287897
Koivusalo
Glutathione-dependent formalde ...
Rattus norvegicus
Adv. Exp. Med. Biol.
328
465-474
1993
-
-
-
-
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2
2
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1
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1
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6
-
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1
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1
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2
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2
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1
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-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287876
Kaulfers
-
Demonstration of formaldehyde ...
Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens
FEMS Microbiol. Lett.
79
335-338
1991
-
-
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6
-
6
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12
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6
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6
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6
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-
12
-
-
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-
-
-
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-
-
-
-
-
-
-
-
287862
Kato
Formaldehyde dehydrogenase fro ...
Candida boidinii, Candida boidinii 2201, Komagataella pastoris, Ogataea angusta, Pichia sp., Pichia sp. NRRL-Y-11328
Methods Enzymol.
188
455-462
1990
-
-
-
-
-
-
15
5
-
-
2
3
-
6
-
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1
1
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-
1
1
15
2
-
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-
5
-
1
8
-
-
-
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-
-
8
-
-
-
-
15
-
5
-
-
2
3
-
-
-
1
-
-
1
1
15
2
-
-
-
-
5
-
1
-
-
-
-
-
-
-
287882
Pronk
-
Energetics of mixotrophic and ...
Acidiphilium acidophilum
Arch. Microbiol.
154
576-583
1990
-
-
-
-
-
-
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1
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2
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287883
Bastide
-
Methanol metabolism in Coryneb ...
Corynebacterium sp., Corynebacterium sp. XG
J. Gen. Microbiol.
135
2869-2874
1989
-
-
-
-
-
-
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-
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2
-
2
-
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4
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1
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1
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2
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287886
Pourmotabbed
Bovine liver formaldehyde dehy ...
Bos taurus
J. Biol. Chem.
264
17384-17388
1989
-
-
-
-
-
-
-
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-
-
1
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1
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1
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2
1
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3
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1
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1
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1
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1
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2
1
-
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-
3
-
-
-
-
-
-
-
-
-
-
33645
Trotsenko
-
Metabolism of non-motile oblig ...
Methylobacillus glycogenes, Methylobacillus sp., Methylobacillus sp. VSB-792, Methylophilus methanolovorus, Protaminobacter candidus
FEMS Microbiol. Lett.
33
293-297
1986
-
-
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5
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4
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5
-
-
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-
-
-
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-
-
-
-
287890
Pourmotabbed
Substrate specificity of bovin ...
Bos taurus
J. Biol. Chem.
261
14240-14244
1986
-
-
-
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1
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2
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1
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1
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1
1
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3
1
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1
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1
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1
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1
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2
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1
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1
1
-
3
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
287877
Roitsch
-
Distribution of dissimilatory ...
Methylobacterium organophilum, Methylomicrobium album
Arch. Microbiol.
143
233-236
1985
-
-
-
-
-
-
-
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-
2
-
2
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4
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2
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2
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2
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-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
80989
Allais
-
Oxidation of methanol by the y ...
Candida boidinii, Kloeckera sp., Komagataella pastoris
Agric. Biol. Chem.
47
1509-1516
1983
-
-
-
-
-
-
15
3
-
-
2
-
-
3
-
-
1
-
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-
1
1
4
2
3
1
3
2
4
1
4
3
-
-
-
-
-
-
3
-
-
-
-
15
-
3
-
-
2
-
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-
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1
-
-
1
1
4
2
3
1
3
2
4
1
4
-
-
-
-
-
-
-
287867
Patel
Microbial oxidation of methano ...
Komagataella pastoris, Komagataella pastoris NRRL-Y-11328
Arch. Biochem. Biophys.
221
135-142
1983
-
-
-
-
-
-
10
5
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-
2
-
-
2
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1
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1
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6
1
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1
1
-
3
-
-
-
-
-
-
3
-
-
-
-
10
-
5
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2
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1
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1
-
6
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
287885
Kato
-
Formaldehyde dehydrogenase fro ...
Pseudomonas putida, Pseudomonas putida F61, Schwanniomyces vanrijiae, Schwanniomyces vanrijiae FT-1
Agric. Biol. Chem.
47
415-416
1983
-
-
-
-
-
-
-
4
-
-
4
-
-
9
-
-
2
-
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-
2
2
8
2
2
-
2
-
2
-
2
2
-
-
-
-
-
-
2
-
-
-
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-
4
-
-
4
-
-
-
-
2
-
-
2
2
8
2
2
-
2
-
2
-
2
-
-
-
-
-
-
-
80988
Kato
-
Oxidation of formaldehyde by r ...
Geotrichum klebahnii, Schwanniomyces vanrijiae
Agric. Biol. Chem.
46
655-661
1982
-
-
-
-
-
-
-
-
-
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-
2
-
2
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4
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2
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2
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2
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287869
Schuette
Formaldehyde dehydrogenase fro ...
Candida boidinii
Methods Enzymol.
89
527-531
1982
-
-
-
-
-
-
7
4
-
-
2
2
-
1
-
-
1
-
-
-
1
-
5
1
1
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-
1
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3
-
-
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-
-
3
-
-
-
-
7
-
4
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2
2
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-
1
-
-
1
-
5
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
287870
Uotila
Formaldehyde dehydrogenase ...
Homo sapiens
Methods Enzymol.
77
314-320
1981
-
-
-
-
-
1
5
5
-
-
-
-
-
1
-
-
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-
1
1
1
10
-
-
-
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-
2
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-
4
-
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-
-
-
-
4
-
-
1
-
5
-
5
-
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-
-
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-
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-
1
1
1
10
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
287871
Uotila
Product inhibition studies of ...
Homo sapiens
Biochim. Biophys. Acta
616
153-157
1980
-
-
-
-
-
-
1
-
-
-
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-
1
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-
1
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2
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2
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-
2
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1
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287872
Eggeling
Direct enzymatic assay for alc ...
Ogataea angusta
Appl. Environ. Microbiol.
39
268-269
1980
-
1
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
-
1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
80983
Uotila
Purification of formaldehyde a ...
Pisum sativum
Arch. Biochem. Biophys.
196
33-45
1979
-
-
-
-
-
2
-
1
-
-
2
-
-
1
-
-
1
-
-
1
1
1
3
1
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
1
-
1
1
1
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
287874
Uotila
A steady-state-kinetic model f ...
Homo sapiens
Biochem. J.
177
869-878
1979
-
-
-
-
-
-
2
4
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-
1
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1
-
1
-
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4
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-
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-
-
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4
-
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4
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2
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4
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-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287875
Kato
Steady-state kinetics of forma ...
Candida boidinii
Biochim. Biophys. Acta
566
12-20
1979
-
-
-
-
-
-
6
-
-
-
-
1
-
1
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-
1
-
-
-
-
3
-
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-
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-
2
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2
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6
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-
1
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3
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-
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287881
Eggeling
-
Derepression and partial insen ...
Ogataea angusta
Eur. J. Appl. Microbiol. Biotechnol.
5
197-202
1978
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1
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1
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2
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1
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1
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1
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2
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287889
Schuette
Purification and properties of ...
Candida boidinii
Eur. J. Biochem.
62
151-160
1976
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1
7
4
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2
1
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1
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1
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1
1
3
1
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1
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1
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1
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1
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7
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4
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2
1
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1
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1
1
3
1
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1
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287888
Uotila
Formaldehyde dehydrogenase fro ...
Bos taurus, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
J. Biol. Chem.
249
7653-7663
1974
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2
10
11
1
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1
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6
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1
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15
1
2
16
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3
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3
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8
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8
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2
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10
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11
1
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1
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1
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15
1
2
16
-
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3
-
3
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287879
Sahm
Microbial assimilation of meth ...
Candida boidinii
Arch. Mikrobiol.
90
263-268
1973
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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2
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1
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287866
Goodman
A comparison of rat and human ...
Homo sapiens, Rattus norvegicus
Biochim. Biophys. Acta
252
489-505
1971
2
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1
4
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2
2
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2
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2
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2
2
1
2
1
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2
2
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4
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2
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4
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1
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4
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2
2
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2
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2
2
1
2
1
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2
2
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287864
Rose
-
Formaldehyde dehydrogenase ...
Saccharomyces cerevisiae
Methods Enzymol.
9
357-360
1966
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1
1
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1
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1
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1
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4
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1
1
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3
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3
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1
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1
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1
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1
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4
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1
1
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287884
Strittmatter
Formaldehyde dehydrogenase, a ...
Bos taurus, Gallus gallus
J. Biol. Chem.
213
445-461
1955
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2
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2
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1
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1
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1
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1
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