Literature summary for 1.1.1.284 extracted from

Sanghani, P.C.; Robinson, H.; Bennett-Lovsey, R.; Hurley, T.D.; Bosron, W.F.
Structure-function relationships in human class III alcohol dehydrogenase (formaldehyde dehydrogenase) (2003), Chem. Biol. Interact., 143-144, 195-200.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals of the binary complex with NAD(H) are grown by a sitting drop vapor diffusion method, where the apoenzyme is equilibrated with a 2 mM NAD+ containing crystallization buffer (0.1 M potassium phosphate, pH 7.1, 12-15% PEG8000, 2 mM DTT, 0.05 mM ZnSO4)	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zinc	contains zinc at the active site	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-(hydroxymethyl)glutathione + NAD+	Homo sapiens	the enzyme plays an important role in the formaldehyde detoxification and reduction of the nitric oxide metabolite	S-formylglutathione + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-(hydroxymethyl)glutathione + NAD+	the enzyme plays an important role in the formaldehyde detoxification and reduction of the nitric oxide metabolite	Homo sapiens	S-formylglutathione + NADH + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)