Literature summary for 1.1.1.284 extracted from

Sanghani, P.C.; Robinson, H.; Bosron, W.F.; Hurley, T.D.
Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes (2002), Biochemistry, 41, 10778-10786.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting-drop vapor-diffusion method at 4°C from a 15-20 mg/ml enzyme solution equilibrated with 0.1 M potassium phosphate buffer pH 6.9-7.1, 0.1 mM ZnSO4, 1 mM dithiothreitol, 12-15% PEG8000. Binary complex with substrate 12-hydroxydodecanoic acid and a ternary complex with NAD+ and the inhibitor dodecanoic acid are determined at 2.0 and 2.3 A resolution by X-ray crystallography using the anomalous diffraction signal of zinc	Homo sapiens

Crystallization (Comment)

Organism

sitting-drop vapor-diffusion method at 4°C from a 15-20 mg/ml enzyme solution equilibrated with 0.1 M potassium phosphate buffer pH 6.9-7.1, 0.1 mM ZnSO4, 1 mM dithiothreitol, 12-15% PEG8000. Binary complex with substrate 12-hydroxydodecanoic acid and a ternary complex with NAD+ and the inhibitor dodecanoic acid are determined at 2.0 and 2.3 A resolution by X-ray crystallography using the anomalous diffraction signal of zinc

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
dodecanoic acid	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zinc	mettaloenzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
12-hydroxydodecanoic acid + glutathione + NAD+	-	Homo sapiens	S-(11-carboxy)undecanyl-glutathione + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
ADH3	-	Homo sapiens
c-ADH	-	Homo sapiens
class III alcohol dehydrogenase	-	Homo sapiens
EC 1.2.1.1	formerly, part transferred	Homo sapiens
FDH	incorrect	Homo sapiens
formaldehyde dehydrogenase	incorrect	Homo sapiens
formaldehyde dehydrogenase (glutathione)	incorrect	Homo sapiens
formic dehydrogenase	incorrect	Homo sapiens
GD-FAlDH	-	Homo sapiens
Glutathione-dependent formaldehyde dehydrogenase	incorrect	Homo sapiens
GS-FDH	incorrect	Homo sapiens
NAD- and glutathione-dependent formaldehyde dehydrogenase	-	Homo sapiens
NAD-dependent formaldehyde dehydrogenase	-	Homo sapiens
NAD-linked formaldehyde dehydrogenase	incorrect	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens