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Literature summary for 1.1.1.284 extracted from

  • Uotila, L.; Mannervik, B.
    A steady-state-kinetic model for formaldehyde dehydrogenase from human liver. A mechanism involving NAD+ and the hemimercaptal adduct of glutathione and formaldehyde as substrates and free glutathione as an allosteric activator of the enzyme (1979), Biochem. J., 177, 869-878.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
ADP-ribose competitive with respect to beta-NAD+ and non-competitive with glutathione Homo sapiens
Alpha-NAD+ competitive with respect to beta-NAD+ and non-competitive with glutathione Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0048
-
beta-NAD+
-
Homo sapiens
0.0301
-
thio-NAD+
-
Homo sapiens
0.0352
-
nicotinamide-hypoxanthine dinucleotide
-
Homo sapiens
0.0509
-
3-acetylpyridine-adenine dinucleotide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ random sequential mechanism Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formaldehyde + glutathione + 3-acetylpyridine-adenine dinucleotide
-
Homo sapiens S-formylglutathione + ?
-
?
formaldehyde + glutathione + NAD+
-
Homo sapiens S-formylglutathione + NADH + H+
-
?
formaldehyde + glutathione + nicotinamide-hypoxanthine dinucleotide
-
Homo sapiens S-formylglutathione + ?
-
?
formaldehyde + glutathione + thio-NAD+
-
Homo sapiens S-formylglutathione + thio-NADH
-
?

Cofactor

Cofactor Comment Organism Structure
3-acetylpyridine adenine dinucleotide can substitute for beta-NAD+ Homo sapiens
NAD+
-
Homo sapiens
nicotinamide hypoxanthine dinucleotide can substitute for beta-NAD+ Homo sapiens
thio-NAD+ can substitute for beta-NAD+ Homo sapiens