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Literature summary for 1.1.1.278 extracted from

  • Hunter, A.C.; Coyle, E.; Morse, F.; Dedi, C.; Dodd, H.T.; Koussoroplis, S.J.
    Transformation of 5-ene steroids by the fungus Aspergillus tamarii KITA: Mixed molecular fate in lactonization and hydroxylation pathways with identification of a putative 3beta-hydroxy-steroid dehydrogenase/DELTA(5)-DELTA(4) isomerase pathway (2008), Biochim. Biophys. Acta, 1791, 110-117.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information 3beta-HSD/isomerase activity only occurs following lactonization of the steroidal ring-D Aspergillus tamarii

Inhibitors

Inhibitors Comment Organism Structure
additional information presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity Aspergillus tamarii

Organism

Organism UniProt Comment Textmining
Aspergillus tamarii
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NADP+ is metabolized through the putative 3beta-HSD/isomerase pathway Aspergillus tamarii ?
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?
dehydroepiandrosterone + NADP+ can also enter a minor hydroxylation pathway Aspergillus tamarii ?
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?
dehydroepiandrosterone + NADP+ can also enter a minor hydroxylation pathway Aspergillus tamarii KITA ?
-
?
pregnenolone + NADP+ is metabolized through the putative 3beta-HSD/isomerase pathway Aspergillus tamarii ?
-
?

Synonyms

Synonyms Comment Organism
3beta-HSD/isomerase
-
Aspergillus tamarii
3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase
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Aspergillus tamarii