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show all sequences of 1.1.1.278

Effect of age on synthesis of the GABAergic steroids 5-alpha-pregnane-3,20-dione and 5-alpha-pregnane-3-alpha-ol-20-one in rat cortex in vitro

Stuerenburg, H.J.; Fries, U.; Iglauer, F.; Kunze, K.; J. Neural Transm. 104, 249-257 (1997)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
male and female WAG/Rij rats
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cerebral cortex
activity below detection limit of 0.1 fmol/mg protein/min
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity below detection limit of 0.1 fmol/mg protein/min
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5alpha-pregnan-3,20-dione + NAD(P)H
activity below detection limit of 0.1 fmol/mg protein/min
639089
Rattus norvegicus
3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+
i.e. 5alpha-pregnan-3beta-ol-20-one
639089
Rattus norvegicus
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cerebral cortex
activity below detection limit of 0.1 fmol/mg protein/min
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity below detection limit of 0.1 fmol/mg protein/min
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5alpha-pregnan-3,20-dione + NAD(P)H
activity below detection limit of 0.1 fmol/mg protein/min
639089
Rattus norvegicus
3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+
i.e. 5alpha-pregnan-3beta-ol-20-one
639089
Rattus norvegicus
r
Other publictions for EC 1.1.1.278
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
691108
Hunter
Transformation of 5-ene steroi ...
Aspergillus tamarii
Biochim. Biophys. Acta
1791
110-117
2008
1
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1
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1
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4
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1
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1
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4
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669941
Petralia
Inhibiting biosynthesis and/or ...
Rattus norvegicus
J. Neuroendocrinol.
17
545-552
2005
-
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1
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1
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389563
Lindemann
-
Biosynthesis of pregnane deriv ...
Digitalis lanata, Digitalis lanata VIII
Phytochemistry
46
507-513
1997
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1
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2
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1
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1
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639089
Stuerenburg
Effect of age on synthesis of ...
Rattus norvegicus
J. Neural Transm.
104
249-257
1997
-
-
-
-
-
-
-
-
-
-
-
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-
1
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1
1
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1
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1
1
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1
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639090
Wiebe
Synthesis, metabolism and leve ...
Rattus norvegicus
Brain Res.
764
158-166
1997
-
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-
-
-
-
-
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2
-
1
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1
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3
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1
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3
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639087
Warneck
3beta-Hydroxysteroid oxidoredu ...
Digitalis lanata
Z. Naturforsch. C
45
963-972
1990
1
-
-
-
-
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9
2
3
-
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1
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1
-
-
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1
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2
-
1
1
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1
1
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4
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1
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4
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9
-
2
3
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1
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1
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2
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1
1
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1
1
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639088
Laine
Progesterone metabolism by maj ...
Rattus norvegicus, Rattus norvegicus Turku
J. Steroid Biochem. Mol. Biol.
37
605-611
1990
-
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-
-
-
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2
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2
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2
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2
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4
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1
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3
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2
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2
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4
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1
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639086
Ichihara
Progesterone metabolism in the ...
Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus
J. Steroid Biochem.
32
835-840
1989
-
-
-
-
-
-
-
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3
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3
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3
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6
2
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6
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2
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1
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4
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4
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3
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3
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6
2
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6
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2
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1
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639085
Giacomini
The effects of progesterone an ...
Homo sapiens
J. Steroid Biochem.
13
645-651
1980
-
-
-
-
-
-
2
-
2
-
-
1
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1
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1
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3
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4
4
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4
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2
4
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2
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1
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1
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3
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