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Literature summary for 1.1.1.278 extracted from

  • Stuerenburg, H.J.; Fries, U.; Iglauer, F.; Kunze, K.
    Effect of age on synthesis of the GABAergic steroids 5-alpha-pregnane-3,20-dione and 5-alpha-pregnane-3-alpha-ol-20-one in rat cortex in vitro (1997), J. Neural Transm., 104, 249-257.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male and female WAG/Rij rats
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Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex activity below detection limit of 0.1 fmol/mg protein/min Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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activity below detection limit of 0.1 fmol/mg protein/min Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H activity below detection limit of 0.1 fmol/mg protein/min Rattus norvegicus 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ i.e. 5alpha-pregnan-3beta-ol-20-one r