Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Cavia porcellus | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NADPH | Cavia porcellus | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | Rattus norvegicus | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | Oryctolagus cuniculus | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Cavia porcellus | - |
gastric mucosa | - |
Cavia porcellus | - |
gastric mucosa | - |
Rattus norvegicus | - |
gastric mucosa | - |
Oryctolagus cuniculus | - |
small intestine | - |
Cavia porcellus | - |
stomach | - |
Cavia porcellus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
additional information | - |
activity is determined as progesterone-metabolizing activity including steroid 5alpha-reductase and 3beta-hydroxysteroid dehydrogenase activity | Cavia porcellus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Cavia porcellus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Oryctolagus cuniculus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | - |
Cavia porcellus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | - |
Rattus norvegicus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | - |
Oryctolagus cuniculus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxy steroid dehydrogenase | - |
Cavia porcellus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cavia porcellus |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Cavia porcellus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Cavia porcellus | |
NADP+ | - |
Rattus norvegicus | |
NADPH | - |
Cavia porcellus | |
NADPH | - |
Rattus norvegicus |