Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.278 extracted from

  • Giacomini, M.; Wright, F.
    The effects of progesterone and pregnanedione on the reductive metabolism of dihydrotestosterone in human skin (1980), J. Steroid Biochem., 13, 645-651.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5alpha-pregnan-3,20-dione
-
Homo sapiens
progesterone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-pregnan-3,20-dione + NADPH Homo sapiens
-
3beta-hydroxy-5alpha-pregnane-20-one + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin pubic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H
-
Homo sapiens 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
r
5alpha-pregnan-3,20-dione + NADPH
-
Homo sapiens 3beta-hydroxy-5alpha-pregnane-20-one + NADP+
-
r
additional information progesterone is no substrate Homo sapiens ?
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ less effective than NADP+ Homo sapiens
NADH less effective than NADPH Homo sapiens
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0095
-
5alpha-pregnan-3,20-dione in presence of NADH Homo sapiens
0.0125
-
5alpha-pregnan-3,20-dione in presence of NADPH Homo sapiens
0.035
-
progesterone in presence of NADH Homo sapiens
0.066
-
progesterone in presence of NADPH Homo sapiens