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Literature summary for 1.1.1.272 extracted from

  • Matelska, D.; Shabalin, I.; Jablonska, J.; Domagalski, M.; Kutner, J.; Ginalski, K.; Minor, W.
    Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases 2HADH knowledgebase (2018), BMC Evol. Biol., 18, 199 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
three crystal structures of DDH_HALMT are solved in complex with combinations of NAD+, NADP+, NADPH, 2-ketohexanoic acid, and 2-hydroxyhexanoic acid (PDB IDs are 5mha, 5mh5, 5mh6) Haloferax mediterranei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei
-
2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei ATCC 33500
-
2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei NBRC 14739
-
2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei JCM 8866
-
2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei R-4
-
2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei DSM 1411
-
2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+ Haloferax mediterranei NCIMB 2177
-
2-D-hydroxyisoleucine + NADP+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei
-
a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei ATCC 33500
-
a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei NBRC 14739
-
a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei JCM 8866
-
a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei R-4
-
a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei DSM 1411
-
a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+ Haloferax mediterranei NCIMB 2177
-
a 2-oxocarboxylate + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Haloferax mediterranei Q2VEQ7
-
-
Haloferax mediterranei ATCC 33500 Q2VEQ7
-
-
Haloferax mediterranei DSM 1411 Q2VEQ7
-
-
Haloferax mediterranei JCM 8866 Q2VEQ7
-
-
Haloferax mediterranei NBRC 14739 Q2VEQ7
-
-
Haloferax mediterranei NCIMB 2177 Q2VEQ7
-
-
Haloferax mediterranei R-4 Q2VEQ7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei ATCC 33500 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei NBRC 14739 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei JCM 8866 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei R-4 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei DSM 1411 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxo-3-methylvalerate + NADPH + H+
-
Haloferax mediterranei NCIMB 2177 2-D-hydroxy-3-methylvalerate + NADP+
-
r
2-oxobutyrate + NADPH + H+
-
Haloferax mediterranei 2-D-hydroxybutyrate + NADP+
-
r
2-oxoisocaproate + NADPH + H+
-
Haloferax mediterranei 2-hydroxyisocaproate + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei 2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei ATCC 33500 2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei NBRC 14739 2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei JCM 8866 2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei R-4 2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei DSM 1411 2-D-hydroxyisoleucine + NADP+
-
r
2-oxoisoleucine + NADPH + H+
-
Haloferax mediterranei NCIMB 2177 2-D-hydroxyisoleucine + NADP+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei ATCC 33500 a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei NBRC 14739 a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei JCM 8866 a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei R-4 a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei DSM 1411 a 2-oxocarboxylate + NADPH + H+
-
r
an (R)-2-hydroxycarboxylate + NADP+
-
Haloferax mediterranei NCIMB 2177 a 2-oxocarboxylate + NADPH + H+
-
r
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei ?
-
-
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei ATCC 33500 ?
-
-
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei NBRC 14739 ?
-
-
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei JCM 8866 ?
-
-
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei R-4 ?
-
-
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei DSM 1411 ?
-
-
additional information the DDH enzyme is a 2-oxocarboxylic reductase with broad substrate specificity. It shows a marked preference for those having an unbranched chain of 4-5 carbon atoms, such as 2-oxoisoleucine. It exhibits dual cofactor specificity, yet shows better catalytic efficiency with NADPH Haloferax mediterranei NCIMB 2177 ?
-
-
pyruvate + NADPH + H+
-
Haloferax mediterranei D-lactate + NADP+
-
r
pyruvate + NADPH + H+
-
Haloferax mediterranei ATCC 33500 D-lactate + NADP+
-
r
pyruvate + NADPH + H+
-
Haloferax mediterranei NBRC 14739 D-lactate + NADP+
-
r
pyruvate + NADPH + H+
-
Haloferax mediterranei JCM 8866 D-lactate + NADP+
-
r
pyruvate + NADPH + H+
-
Haloferax mediterranei R-4 D-lactate + NADP+
-
r
pyruvate + NADPH + H+
-
Haloferax mediterranei DSM 1411 D-lactate + NADP+
-
r
pyruvate + NADPH + H+
-
Haloferax mediterranei NCIMB 2177 D-lactate + NADP+
-
r

Synonyms

Synonyms Comment Organism
2HADH
-
Haloferax mediterranei
D-2-hydroxyacid dehydrogenase
-
Haloferax mediterranei
D-isomer specific 2-hydroxyacid dehydrogenase
-
Haloferax mediterranei
DDH
-
Haloferax mediterranei
DDH_HALMT
-
Haloferax mediterranei

Cofactor

Cofactor Comment Organism Structure
additional information the enzyme prefers NADPH over NADH Haloferax mediterranei
NADP+
-
Haloferax mediterranei
NADPH
-
Haloferax mediterranei

General Information

General Information Comment Organism
evolution the enzyme belongs to the family of D-isomer specific 2-hydroxyacid dehydrogenases (2HADHs) that contains a wide range of oxidoreductases with various metabolic roles as well as biotechnological applications. The family comprises 22 subfamilies, the enzyme from Haloferax mediterranei belongs to the DDH subfamily, phylogenetic analysis and tree, overview Haloferax mediterranei
additional information sequence-structure-function relationships, overview Haloferax mediterranei