Literature summary for 1.1.1.270 extracted from

Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process (2015), PLoS ONE, 10, e113194.

Search for more literature for 1.1.1.270

Inhibitors

Inhibitors	Comment	Organism	Structure
trilostane	-	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary cultured hepatocyte	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
androstenone + NAD(P)H + H+	-	Sus scrofa	5alpha-androst-16-en-3beta-ol + NAD(P)+	-	?

General Information

General Information	Comment	Organism
physiological function	3betaHSD is essential for metabolism of androstenone to 5alpha-androst-16-en-3beta-ol, which then forms androstenone glucuronide conjugate. 3betaHSD is not involved in 17beta-estradiol metabolism	Sus scrofa

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)