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Literature summary for 1.1.1.27 extracted from

  • Suzuki, K.; Maeda, S.; Morokuma, K.
    Roles of closed- and open-loop conformations in large-scale structural transitions of L-lactate dehydrogenase (2019), ACS omega, 4, 1178-1184 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P13491
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Source Tissue

Source Tissue Comment Organism Textmining
muscle
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 Oryctolagus cuniculus
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Synonyms

Synonyms Comment Organism
LdhA
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 Oryctolagus cuniculus

General Information

General Information Comment Organism
metabolism the substrate binding and product states are stabilized only in the open-loop conformation of LDH and the reaction occurs in the closed-loop conformation, i.e., before and after the chemical reaction, a large-scale structural transition from the open-loop conformation to the closed-loop conformation and vice versa occurs. The closed-loop conformation stabilizes the transition state of the reaction. In contrast, the open-loop conformation stabilizes the substrate binding and final states Oryctolagus cuniculus