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Literature summary for 1.1.1.27 extracted from
- Purification and properties of L(+)-lactate dehydrogenase from potato tubers (1972), Biochem. J., 129, 831-839.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-glycerophosphate | activation | Solanum tuberosum |  |
| 3-phosphoglycerate | activation | Solanum tuberosum | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Solanum tuberosum | |
| ATP | at neutral or alkaline pH ATP behaves as a weak competitive inhibitor, potent inhibitor at acid pH values | Solanum tuberosum | |
| GTP | - |
Solanum tuberosum | |
| NAD+ | product inhibition | Solanum tuberosum | |
| NADH | competitive with respect to NAD+ | Solanum tuberosum | |
| oxalate | - |
Solanum tuberosum | |
| phosphoenolpyruvate | - |
Solanum tuberosum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
pyruvate | - |
Solanum tuberosum | |
| 8 | - |
Hydroxypyruvate | - |
Solanum tuberosum | |
| 25 | - |
glyoxylate | - |
Solanum tuberosum | |
| 77 | - |
2-oxobutanoate | - |
Solanum tuberosum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Solanum tuberosum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Solanum tuberosum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| tuber | - |
Solanum tuberosum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 18.5 | - |
- |
Solanum tuberosum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxobutyrate + NADH | - |
Solanum tuberosum | 2-hydroxybutyrate + NAD+ | - |
? | |
| glyoxylate + NADH | - |
Solanum tuberosum | glycolate + NAD+ | - |
? | |
| hydroxypyruvate + NADPH + H+ | - |
Solanum tuberosum | 2,3-dihydroxypropanoate + NADP+ | - |
? | |
| pyruvate + NADH + H+ | - |
Solanum tuberosum | (S)-lactate + NAD+ | - |
? | |
| pyruvate + NADPH + H+ | - |
Solanum tuberosum | (S)-lactate + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
reduction of oxo acids with NADH or NADPH | Solanum tuberosum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | coenzyme | Solanum tuberosum | |
| NADPH | coenzyme | Solanum tuberosum | |
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Release 2023.1 (January 2023)
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