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Literature summary for 1.1.1.268 extracted from

  • Boyd, J.M.; Clark, D.D.; Kofoed, M.A.; Ensign, S.A.
    Mechanism of inhibition of aliphatic epoxide carboxylation by the coenzyme M analog 2-bromoethanesulfonate (2010), J. Biol. Chem., 285, 25232-25242.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-bromoethanesulfonate CoM-analogue, mixed type inhibitor. 32.7% residual activity at 5 mM, reversible inhibition Xanthobacter autotrophicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.124
-
2-(R)-hydroxypropyl-CoM pH 7.4, 30°C Xanthobacter autotrophicus

Organism

Organism UniProt Comment Textmining
Xanthobacter autotrophicus Q56840
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(R)-hydroxypropyl-CoM + NAD+
-
Xanthobacter autotrophicus 2-oxopropyl-CoM + NADH + H+
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
29
-
2-(R)-hydroxypropyl-CoM pH 7.4, 30°C Xanthobacter autotrophicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2
-
2-bromoethanesulfonate pH 7.4, 30°C Xanthobacter autotrophicus