Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | use of the Dxr-fosmidomycin cocrystal structure to design bisubstrate ligands to bind to both the 1-deoxy-D-xylulose-5-phosphate and NADPH sites | Mycobacterium tuberculosis | |
[3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid | compound binds to Dxr via a non-bisubstrate mechanism. The diethyl ester of [3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid inhibits Mycobacterium tuberculosis growth | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
DXR | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0178 | - |
pH not specified in the publication, temperature not specified in the publication | Mycobacterium tuberculosis | [3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid |