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Literature summary for 1.1.1.267 extracted from

  • Jawaid, S.; Seidle, H.; Zhou, W.; Abdirahman, H.; Abadeer, M.; Hix, J.H.; van Hoek, M.L.; Couch, R.D.
    Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase) (2009), PLoS ONE, 4, e8288.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Francisella tularensis

Crystallization (Commentary)

Crystallization (Comment) Organism
homology modeling based on the Escherichia coli homolog Francisella tularensis

Protein Variants

Protein Variants Comment Organism
S177D inactive Francisella tularensis
S177E inactive Francisella tularensis

Inhibitors

Inhibitors Comment Organism Structure
fosmidomycin
-
Francisella tularensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0133
-
NADPH pH 7.8, 22°C Francisella tularensis
0.1037
-
1-deoxy-D-xylulose 5-phosphate pH 7.8, 22°C Francisella tularensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42700
-
2 * 42700, calculated Francisella tularensis
94000
-
gel filtration Francisella tularensis

Organism

Organism UniProt Comment Textmining
Francisella tularensis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein residue S177 is the site of phosphorylation Francisella tularensis

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Francisella tularensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 42700, calculated Francisella tularensis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3
-
NADPH pH 7.8, 22°C Francisella tularensis
2
-
1-deoxy-D-xylulose 5-phosphate pH 7.8, 22°C Francisella tularensis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000989
-
fosmidomycin pH 7.8, 22°C Francisella tularensis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000247
-
pH 7.8, 22°C Francisella tularensis fosmidomycin

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
20
-
1-deoxy-D-xylulose 5-phosphate pH 7.8, 22°C Francisella tularensis