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Literature summary for 1.1.1.262 extracted from

  • Cane, D.E.; Hsiung, Y.; Cornish, J.A.; Robinson, J.K.; Spenser, I.D.
    Biosynthesis of vitamin B6: the oxidation of 4-(phosphohydroxy)-L-threonine by PdxA (1998), J. Am. Chem. Soc., 120, 1936-1937.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-(phosphohydroxy)-L-threonine + NAD+ Escherichia coli involved in pyridoxal 5'-phosphate formation 2-amino-3-oxo-4-phosphohydroxybutyrate + NADH undergoes decarboxylation either catalysed by the enzyme or after release, further formation of pyridoxal 5'-phosphate catalysed by PdxJ protein r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, recombinant enzyme Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
additional information pdxA gene product Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(phosphohydroxy)-L-threonine + NAD+ involved in pyridoxal 5'-phosphate formation Escherichia coli 2-amino-3-oxo-4-phosphohydroxybutyrate + NADH undergoes decarboxylation either catalysed by the enzyme or after release, further formation of pyridoxal 5'-phosphate catalysed by PdxJ protein r

Subunits

Subunits Comment Organism
monomer gel filtration, native PAGE, SDS-PAGE Escherichia coli