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Literature summary for 1.1.1.262 extracted from

  • Cane, D.E.; Du, S.; Robinson, J.K.; Hsiung, Y.; Spenser, I.D.
    Biosynthesis of vitamin B6: enzymatic conversion of 1-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate (1999), J. Am. Chem. Soc., 121, 7722-7723.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
EDTA inhibition at 1 mM, fully restored by addition of 1 mM Mn2+, Co2+, Mg2+ or Ca2+, partially restored by 1 mM Ni2+ or Zn2+ Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-(phosphohydroxy)-L-threonine + NAD+ Escherichia coli involved in pyridoxal 5'-phosphate formation 3-phosphohydroxy-1aminoacetone + CO2 + NADH + H+ further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, recombinant enzyme Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
additional information pdxA gene product Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(phosphohydroxy)-L-threonine + NAD+ involved in pyridoxal 5'-phosphate formation Escherichia coli 3-phosphohydroxy-1aminoacetone + CO2 + NADH + H+ further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate r