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Literature summary for 1.1.1.262 extracted from

  • Laber, B.; Maurer, W.; Scharf, S.; Stepusin, K.; Schmidt, F.S.
    Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein (1999), FEBS Lett., 449, 45-48.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-(phosphohydroxy)-L-threonine + NAD+ Escherichia coli involved in pyridoxal 5'-phosphate formation 2-amino-3-oxo-4-phosphohydroxybutyrate + NADH further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, recombinant enzyme Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
additional information pdxA gene product Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(phosphohydroxy)-L-threonine + NAD+ involved in pyridoxal 5'-phosphate formation Escherichia coli 2-amino-3-oxo-4-phosphohydroxybutyrate + NADH further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4
-
4-(phosphohydroxy)-L-threonine
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli