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Literature summary for 1.1.1.23 extracted from

  • Grubmeyer, C.T.; Gray, W.R.
    A cysteine residue (cysteine-116) in the histidinol binding site of histidinoldehydrogenase (1986), Biochemistry, 25, 4778-4784.
    View publication on PubMed
Search for more literature for 1.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
7-chloro-4-nitro-2,1,3-benzoxadiazole 0.1 mM, pseudo first order inactivation, binds to Cys-116 in active site Salmonella enterica subsp. enterica serovar Typhimurium
histamine competitive inhibition Salmonella enterica subsp. enterica serovar Typhimurium
imidazole competitive inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidinal + NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium reaction intermediate L-histidine + NADH + H+
-
 ?
L-histidinol + 2 NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 L-histidine + 2 NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidinal + NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
 ?
L-histidinal + NAD+ + H2O reaction intermediate Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
 ?
L-histidinol + 2 NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 2 H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium