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Literature summary for 1.1.1.226 extracted from

  • Taylor, D.G.; Trudgill, P.
    Metabolism of cyclohexane caroxylic acid by Alcaligenes strain W1 (1978), J. Bacteriol., 5, 401-411.
No PubMed abstract available
Search for more literature for 1.1.1.226

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-4-hydroxycyclohexanecarboxylate + NAD+ Alcaligenes sp. enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway 4-oxocyclohexanecarboxylate + NADH
-
 ?
trans-4-hydroxycyclohexanecarboxylate + NAD+ Alcaligenes sp. W1 enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway 4-oxocyclohexanecarboxylate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Alcaligenes sp.
-
-
-
Alcaligenes sp. W1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-4-hydroxycyclohexanecarboxylate + NAD+
-
 Alcaligenes sp. 4-oxocyclohexanecarboxylate + NADH
-
 ?
trans-4-hydroxycyclohexanecarboxylate + NAD+ enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway Alcaligenes sp. 4-oxocyclohexanecarboxylate + NADH
-
 ?
trans-4-hydroxycyclohexanecarboxylate + NAD+
-
 Alcaligenes sp. W1 4-oxocyclohexanecarboxylate + NADH
-
 ?
trans-4-hydroxycyclohexanecarboxylate + NAD+ enzyme of the oxidative branch of the 2-hydroxy-4-carboxymucoic semialdehyde-cleaving pathway Alcaligenes sp. W1 4-oxocyclohexanecarboxylate + NADH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 NADH oxidation Alcaligenes sp.
10
-
 NAD reduction Alcaligenes sp.

Cofactor

Cofactor Comment Organism Structure
NAD+ very specific, no activity with NADP+ Alcaligenes sp.
NADH very specific, no activity with NADPH Alcaligenes sp.