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Literature summary for 1.1.1.22 extracted from
- Uridine diphosphoglucose dehydrogenase from rat liver: purification and effect of pH on regulatory properties (1972), Biochim. Biophys. Acta, 276, 43-52.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| UDPxylose | - |
Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0756 | - |
UDPglucose | native enzyme | Rattus norvegicus | |
| 1 | - |
UDPglucose | dissociated enzyme | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no metal ion requirement | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
4 * 70000, gel filtration after treatment with SDS | Rattus norvegicus |
| 300000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDPglucose + NAD+ + H2O | Rattus norvegicus | - |
UDPglucuronate + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + 2 NAD+ + H2O | - |
Rattus norvegicus | UDP-glucuronate + 2 NADH + 2 H+ | - |
? | |
| UDPglucose + NAD+ + H2O | - |
Rattus norvegicus | UDPglucuronate + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 70000, gel filtration after treatment with SDS | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.4 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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