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Literature summary for 1.1.1.214 extracted from

  • Julliard, J.H.
    Purification and characterization of oxopantoyl lactone reductase from higher plants: role in pantothenate synthesis (1994), Bot. Acta, 107, 191-200.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2-keto-4-hydroxybutyrolactone strong and uncompetitive inhibitor Spinacia oleracea
substituted 2,5-dioxopyrrolidines strong and uncompetitive inhibitors Spinacia oleracea

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
Spinacia oleracea 9507
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000 36000
-
Spinacia oleracea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ketopantoyl lactone + NADPH Spinacia oleracea
-
pantoyl lactone + NADP+ the enzyme is involved in pantothenate biosynthesis, pantoyl lactone, the putative product of the reaction, together with beta-alanine and ATP are the substrate of pantothenate synthase ?

Organism

Organism UniProt Comment Textmining
Spinacia oleracea
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using affinity chromatography on Red-Agarose and several subsequent ion exchange steps Spinacia oleracea

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Spinacia oleracea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acenaphthenequinone
-
Spinacia oleracea ?
-
?
bornanedione + NADPH
-
Spinacia oleracea ?
-
?
isatin + NADPH
-
Spinacia oleracea ?
-
?
ketopantoyl lactone + NADPH
-
Spinacia oleracea pantoyl lactone + NADP+
-
?
ketopantoyl lactone + NADPH
-
Spinacia oleracea pantoyl lactone + NADP+ the enzyme is involved in pantothenate biosynthesis, pantoyl lactone, the putative product of the reaction, together with beta-alanine and ATP are the substrate of pantothenate synthase ?

Subunits

Subunits Comment Organism
monomer 1 * 33000-36000 Spinacia oleracea