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Literature summary for 1.1.1.213 extracted from

  • Azzarello, J.; Fung, K.M.; Lin, H.K.
    Tissue distribution of human AKR1C3 and rat homolog in adult genitourinary system (2008), J. Histochem. Cytochem., 56, 853-861.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of AKR1C9 in Escherichia coli Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
cytoplasm
-
Rattus norvegicus 5737
-
additional information tissue-dependent subcellular localization, overview Homo sapiens
-
-
additional information tissue-dependent subcellular localization, overview Rattus norvegicus
-
-
nucleus
-
Homo sapiens 5634
-
nucleus
-
Rattus norvegicus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
x * 37000, SDS-PAGE Rattus norvegicus
74000 75000 native PAGE, kidney enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression ?
-
?
additional information Rattus norvegicus AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder
-
Rattus norvegicus
-
bladder the urothelial epithelium lining the renal pelvis is strongly immunoreactive, but stromal cells in the underlying supporting connective tissue are negative Homo sapiens
-
epididymis no activity in the stromal cells or endothelial cells, but weak immunoreactivity in the epididymal epithelial cells Rattus norvegicus
-
epididymis only a small number of epithelial cells are immunoreactive with both nuclear and cytoplasmic reactivity Homo sapiens
-
epithelial cell
-
Homo sapiens
-
epithelial cell
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
kidney in renal cortex, endothelial cells of the glomeruli lack immunoreactivity for AKR1C3, but the Bowman’s capsule and mesangial cells are strongly reactive, as well as larger epithelial cells of the medulla, overview Homo sapiens
-
additional information tissue distribution of AKR1C3, immunohistochemic analysis, overview Homo sapiens
-
additional information tissue distribution of AKR1C9, immunohistochemic analysis, overview Rattus norvegicus
-
prostate
-
Homo sapiens
-
prostate gland epithelial cells, but not the stromal cells or endothelial cells Rattus norvegicus
-
testis
-
Rattus norvegicus
-
testis in Leydig cells, but no or poor activity in germ cells and Sertoli cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression Homo sapiens ?
-
?
additional information AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 37000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
AKR1C3
-
Homo sapiens
AKR1C9
-
Rattus norvegicus
More cf. EC 1.1.1.50 Homo sapiens
More cf. EC 1.1.1.50 Rattus norvegicus
type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase
-
Homo sapiens