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Literature summary for 1.1.1.213 extracted from
- Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues (2006), J. Steroid Biochem. Mol. Biol., 98, 18-24.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence analysis and comparison | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | an androgen-inactivating enzyme, important in androgen and progesterone metabolism | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | same expression level in female and male livers | Mus musculus | - |
| additional information | the androgen-inactivating enzyme is selectively expressed in female tissue, while it is mostly absent in male tissue, tissue distribution, overview | Mus musculus | - |
| pituitary gland | 6fold higher expression level in female than in male pituitary | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5alpha-androstanedione + NADPH + H+ | - |
Mus musculus | 5alpha-androstan-3alpha-ol-17-one + NADP+ | i.e. allopregnanolone | ? | |
| 5alpha-dihydrotestosterone + NADPH | i.e. DHT | Mus musculus | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| dihydroprogesterone + NADPH | - |
Mus musculus | androsterone + NADP+ | - |
? | |
| additional information | an androgen-inactivating enzyme, important in androgen and progesterone metabolism | Mus musculus | ? | - |
? | |
| additional information | the enzyme might play an important role in female physiology, substrate specificity, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3alpha-hydroxysteroid dehydrogenase | - |
Mus musculus |
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