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Literature summary for 1.1.1.21 extracted from

  • Obrosova, I.G.; Maksimchyk, Y.; Pacher, P.; Agardh, E.; Smith, M.L.; El-Remessy, A.B.; Agardh, C.D.
    Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina (2010), Int. J. Mol. Med., 26, 135-142.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
fidarestat
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + NADPH + H+ Rattus norvegicus
-
sorbitol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + NADPH + H+
-
Rattus norvegicus sorbitol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism aldose reductase is the first enzyme in the polyol pathway and reduces glucose to sorbitol utilizing NADPH as a cofactor. Sorbitol is then metabolized to fructose by sorbitol dehydrogenase Rattus norvegicus
physiological function aldose reductase inhibition reduces sorbitol accumulation and cell death in ischemia-reperfusion injury in the retina, phenotype, overview Rattus norvegicus