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Literature summary for 1.1.1.21 extracted from

  • Srivastava, S.; Vladykovskaya, E.; Barski, O.A.; Spite, M.; Kaiserova, K.; Petrash, J.M.; Chung, S.S.; Hunt, G.; Dawn, B.; Bhatnagar, A.
    Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice (2009), Circ. Res., 105, 793-802.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
sorbinil
-
 Mus musculus
Tolrestat
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 apolipoprotein E-null mice
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
blood vessel
-
 Mus musculus
-
smooth muscle
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function aldose reductase metabolizes both free and phospholipid aldehydes and exacerbates atherosclerotic lesion formation, increase in lesion area attributable to inhibition of the enzyme or deletion of the gene encoding the enzyme occurs in both male and female mice, phenotype of enzyme-deficient male and female mice with increases in arterial lesions, macrophage accumulation and interstitial fibrosis, and decreases smooth muscle cell content of arterial lesions, detailed overview Mus musculus