Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | gene expression in YPEN-1 and NRK cells is up-regulated by treatments with submicromolar concentrations of hydrogen peroxide and 1,4-naphthoquinone, but not with fibroblast growth factor-1, fibroblast growth factor-2, 5alpha-dihydrotestosterone and 17beta-estradiol | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli and in YPEN-1 and NRK cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3',3'',5',5''-tetrabromophenolphthalein | less than 25% inhibition at 0.1 mM | Rattus norvegicus | |
Barbital | less than 25% inhibition at 0.5 mM | Rattus norvegicus | |
benzbromarone | - |
Rattus norvegicus | |
daidzein | - |
Rattus norvegicus | |
Diphenic acid | less than 25% inhibition at 0.5 mM | Rattus norvegicus | |
fidarestat | - |
Rattus norvegicus | |
Hexestrol | - |
Rattus norvegicus | |
indomethacin | less than 25% inhibition at 0.1 mM | Rattus norvegicus | |
Medroxyprogesterone acetate | less than 25% inhibition at 0.01 mM | Rattus norvegicus | |
minalrestat | - |
Rattus norvegicus | |
additional information | the enzyme activity is not affected by 0.1 mM Wy14643 | Rattus norvegicus | |
myricetin | - |
Rattus norvegicus | |
quercetin | - |
Rattus norvegicus | |
sorbinil | - |
Rattus norvegicus | |
Tolrestat | - |
Rattus norvegicus | |
Valproate | less than 25% inhibition at 0.5 mM | Rattus norvegicus | |
zearalenone | - |
Rattus norvegicus | |
zopolrestat | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
4-nitrobenzaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.005 | - |
1-nonanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.0055 | - |
1-decanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.0057 | - |
16-ketoestrone | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.0065 | - |
2,3-heptanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.0095 | - |
21-Dehydrocortisol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.01 | - |
2-decenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.012 | - |
Pyridine-3-aldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.014 | - |
2,3-Hexanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.014 | - |
1-octanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.015 | - |
1-butanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.016 | - |
Phenylglyoxal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.017 | - |
2-nonenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.02 | - |
Pyridine-4-aldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.023 | - |
1-hexanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.03 | - |
4-hydroxynonenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.048 | - |
2,4-decadienal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.052 | - |
2-phenyl-2-propenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.056 | - |
phenyl-1,2-propanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.063 | - |
benzaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.064 | - |
2,4-nonadienal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.069 | - |
isatin | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.07 | - |
3-deoxyglucosone | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.073 | - |
D-lactoaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.075 | - |
2-hexenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.082 | - |
1-Decanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.12 | - |
acrolein | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
2,3-Pentanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
(1S)-Camphorquinone | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.26 | - |
methylglyoxal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.3 | - |
1-propanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.31 | - |
3,4-hexanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.68 | - |
2,3-Butanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.74 | - |
1-nonanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.78 | - |
2-phenyl-1-propanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.97 | - |
1-Hexanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
1.28 | - |
Glyoxal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
1.5 | - |
glycoaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
2 | - |
DL-glyceraldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
2.1 | - |
benzyl alcohol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
63 | - |
1-butanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
gel filtration | Rattus norvegicus |
36000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Q-Sepharose column chromatography and Sephadex G-100 gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Rattus norvegicus | - |
colon | - |
Rattus norvegicus | - |
endothelial cell | - |
Rattus norvegicus | - |
fibroblast | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
additional information | the mRNA is detected in all rat tissues besides the brain, but contents in rat tissues other than the lung, stomach and adrenal gland are low | Rattus norvegicus | - |
ovary | - |
Rattus norvegicus | - |
small intestine | - |
Rattus norvegicus | - |
stomach | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1S)-camphorquinone + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
(S)-1-indanol + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
(S)-1-tetralol + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
1-butanal + NADPH + H+ | - |
Rattus norvegicus | 1-butanol + NADP+ | - |
? | |
1-decanal + NADPH + H+ | - |
Rattus norvegicus | 1-decanol + NADP+ | - |
? | |
1-hexanal + NADPH + H+ | - |
Rattus norvegicus | 1-hexanol + NADP+ | - |
? | |
1-nonanal + NADPH + H+ | - |
Rattus norvegicus | 1-nonanol + NADP+ | - |
? | |
1-propanal + NADPH + H+ | - |
Rattus norvegicus | 1-propanol + NADP+ | - |
? | |
16-ketoestrone + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2,3-butanedione + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2,3-heptanedione + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2,3-hexanedione + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2,3-pentanedione + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2,4-decadienal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2,4-nonadienal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2-decenal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2-hexenal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2-nonenal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
2-phenyl-2-propenal + NADPH + H+ | - |
Rattus norvegicus | 2-phenyl-1-propanol + NADP+ | - |
? | |
21-dehydrocortisol + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
3,4-hexanedione + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
3-deoxyglucosone + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
4-hydroxynonenal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
4-nitrobenzaldehyde + NADPH + H+ | - |
Rattus norvegicus | 4-nitrobenzyl alcohol + NADP+ | - |
? | |
acrolein + NADPH + H+ | - |
Rattus norvegicus | 2-propen-1-ol + NADP+ | - |
? | |
benzaldehyde + NADPH + H+ | - |
Rattus norvegicus | benzyl alcohol + NADP+ | - |
? | |
D-lactoaldehyde + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
DL-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
? | |
glycoaldehyde + NADPH + H+ | - |
Rattus norvegicus | ethylene glycol + NADP+ | - |
? | |
glyoxal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
isatin + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
methylglyoxal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
additional information | exhibits low NADP+-linked dehydrogenase activity towards aliphatic and aromatic alcohols | Rattus norvegicus | ? | - |
? | |
additional information | no NADH-linked reductase activity is observed | Rattus norvegicus | ? | - |
? | |
octanal + NADPH + H+ | - |
Rattus norvegicus | 1-octanol + NADP+ | - |
? | |
phenyl-1,2-propanedione + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
phenylglyoxal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
pyridine-3-aldehyde + NADPH + H+ | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
? | |
pyridine-3-methanol + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
pyridine-4-aldehyde + NADPH + H+ | - |
Rattus norvegicus | 4-hydroxypyridine + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKR1B13 | - |
Rattus norvegicus |
aldo-keto reductase | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
Pyridine-3-methanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.003 | - |
(S)-1-tetralol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.007 | - |
(S)-1-indanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.012 | - |
2-phenyl-1-propanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.023 | - |
1-Decanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.0383 | - |
benzyl alcohol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.062 | - |
1-nonanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.068 | - |
1-Hexanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.13 | - |
1-propanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.137 | - |
1-butanol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.145 | - |
2-decenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.155 | - |
2-nonenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.183 | - |
4-hydroxynonenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.183 | - |
16-ketoestrone | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
Glyoxal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
glycoaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
3-deoxyglucosone | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
2,4-decadienal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
21-Dehydrocortisol | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.2 | - |
2,4-nonadienal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.233 | - |
3,4-hexanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.25 | - |
2,3-Hexanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.27 | - |
acrolein | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.283 | - |
isatin | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.283 | - |
D-lactoaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.333 | - |
2,3-Butanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.333 | - |
(1S)-Camphorquinone | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.35 | - |
1-decanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.383 | - |
2,3-Pentanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.383 | - |
phenyl-1,2-propanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.42 | - |
benzaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.42 | - |
Phenylglyoxal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.43 | - |
methylglyoxal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.43 | - |
2-phenyl-2-propenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.52 | - |
Pyridine-3-aldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.57 | - |
4-nitrobenzaldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.57 | - |
1-nonanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.583 | - |
DL-glyceraldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.6 | - |
2,3-heptanedione | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.63 | - |
Pyridine-4-aldehyde | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.67 | - |
2-hexenal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.67 | - |
1-butanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.7 | - |
1-octanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | |
0.75 | - |
1-hexanal | in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | the NADPH-linked pyridine-3-aldehyde reductase activity is gradually increased by decreasing pH from 8.0 to 6.0 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | strict coenzyme specificity for NADPH | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00003 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | |
0.0006 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | minalrestat | |
0.0008 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | Tolrestat | |
0.0008 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | benzbromarone | |
0.0032 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | Hexestrol | |
0.0068 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | myricetin | |
0.0085 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | fidarestat | |
0.01 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | daidzein | |
0.025 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | zearalenone | |
0.03 | - |
in 0.1 M potassium phosphate, pH 7.4 | Rattus norvegicus | sorbinil |