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Literature summary for 1.1.1.21 extracted from

  • Jung, H.A.; Yoon, N.Y.; Bae, H.J.; Min, B.S.; Choi, J.S.
    Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase (2008), Arch. Pharm. Res., 31, 1405-1412.
    View publication on PubMed
Search for more literature for 1.1.1.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
coptisine 53.85-61.54% inhibition at 0.075 mg/ml Homo sapiens
coptisine 85.86-86.87% inhibition at 0.05 mg/ml Rattus norvegicus
epiberberine 69.23-76.92% inhibition at 0.075 mg/ml Homo sapiens
epiberberine complete inhibition at 0.05 mg/ml Rattus norvegicus
groenlandicine 69.23-76.92% inhibition at 0.075 mg/ml Homo sapiens
groenlandicine 52.38-60.32% inhibition at 0.05 mg/ml Rattus norvegicus
jateorrhizine 12.68-14.08% inhibition at 0.05 mg/ml Rattus norvegicus
magnoflorine 18.33-29.85% inhibition at 0.05 mg/ml Rattus norvegicus
additional information berberine and palmatine exhibit no RLAR inhibitory activities within the test concentration of 0.012.5-0.05 mg/ml; extract and fractions of the rhizome of Coptis chinensis exhibit broad and moderate RLAR inhibitory activities of approximately 0.038.9-0.067.5 mg/ml Rattus norvegicus
quercetin
-
 Homo sapiens
quercetin 76.47-77.94% inhibition at 0.005 mg/ml Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 ?
DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens
aldose reductase
-
 Rattus norvegicus
HRAR
-
 Homo sapiens
RLAR
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0188
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus quercetin
0.1
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus epiberberine
0.1184
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus coptisine
0.1401
-
 in 100 mM sodium phosphate buffer (pH 6.2) Rattus norvegicus groenlandicine
0.1542
-
 in 100 mM sodium phosphate buffer (pH 6.2) Homo sapiens groenlandicine
0.1681
-
 in 100 mM sodium phosphate buffer (pH 6.2) Homo sapiens epiberberine
0.1873
-
 in 100 mM sodium phosphate buffer (pH 6.2) Homo sapiens coptisine