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Literature summary for 1.1.1.21 extracted from

  • Cecconi, I.; Scaloni, A.; Rastelli, G.; Moroni, M.; Vilardo, P.G.; Costantino, L.; Cappiello, M.; Garland, D.; Carper, D.; Petrash, J.M.; Del Corso, A.; Mura, U.
    Oxidative modification of aldose reductase induced by copper ion. Definition of the metal-protein interaction mechanism (2002), J. Biol. Chem., 277, 42017-42027.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C298S similar sensitivity against Cu2+ as wild-type Homo sapiens
C298S similar sensitivity against Cu2+ as wild-type Rattus norvegicus
C303S insensitive to inactivation by CuCl2 Homo sapiens

General Stability

General Stability Organism
enzyme is not stable unless dithiothreitol in micromolar range is present Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
CuCl2 addition of dithiothreitol or 2-mercaptoethanol recovers activity Bos taurus
CuCl2 0.007 mM, 20% residual activity, addition of dithiothreitol recovers activity Homo sapiens
CuCl2 0.007 mM, 20% residual activity, addition of dithiothreitol recovers activity Rattus norvegicus
additional information scarcely inhibitory: sorbinil Bos taurus
additional information scarcely inhibitory: sorbinil Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35700
-
x * 35700, electrospray ionisation mass spectrometry data Homo sapiens
35960
-
x * 35960, electrospray ionisation mass spectrometry data Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-
lens
-
Bos taurus
-
placenta
-
Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 35700, electrospray ionisation mass spectrometry data Homo sapiens
? x * 35960, electrospray ionisation mass spectrometry data Bos taurus