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Literature summary for 1.1.1.21 extracted from

  • Ruiz, F.; Hazemann, I.; Mitschler, A.; Joachimiak, A.; Schneider, T.; Karplus, M.; Podjarny, A.
    The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48 (2004), Acta Crystallogr. Sect. D, 60, 1347-1354.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor IDD552, crystallized at pH 5 and 8 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
[5-fluoro-2-[[[(4,5,7-trifluoro-2-benzothiazolyl)methyl]amino]carbonyl]phenoxy]acetic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-

Reaction

Reaction Comment Organism Reaction ID
alditol + NAD(P)+ = aldose + NAD(P)H + H+ mechanism, proton is donated by Tyr48 hydroxyl to the substrate Homo sapiens