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Literature summary for 1.1.1.21 extracted from

  • Ansari, N.H.; Bhatnagar, A.; Liu, S.; Srivastava, S.K.
    Purification and characterization of aldose reductase and aldehyde reductase from human kidney (1991), Biochem. Int., 25, 755-765.
    View publication on PubMed
Search for more literature for 1.1.1.21

Activating Compound

Activating Compound Comment Organism Structure
NaCl increased concentration Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(NH4)2SO4 0.05 mM: slight inhibition, 400 mM: activation Homo sapiens
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
-
 Homo sapiens
Alrestatin
-
 Homo sapiens
dithiothreitol increased inhibitory effect of sorbinil Homo sapiens
Li2SO4 0.4 M: essential for full activity Homo sapiens
Phenobarbital
-
 Homo sapiens
quercetin
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 4-carboxybenzaldehyde
-
 Homo sapiens
0.007
-
 p-nitrobenzaldehyde
-
 Homo sapiens
0.02
-
 4-bromobenzaldehyde
-
 Homo sapiens
0.025
-
 benzaldehyde
-
 Homo sapiens
0.049
-
 NADPH
-
 Homo sapiens
0.152
-
 D-glucuronate
-
 Homo sapiens
29.77
-
 xylose
-
 Homo sapiens
130.2
-
 galactose
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
 alditol + NAD(P)+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.333
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-bromobenzaldehyde + NADPH + H+
-
 Homo sapiens 4-bromobenzyl alcohol + NADP+
-
 r
4-carboxybenzaldehyde + NADPH + H+
-
 Homo sapiens 4-carboxybenzyl alcohol + NADP+
-
 r
4-nitrobenzaldehyde + NAD(P)H
-
 Homo sapiens 4-nitrobenzyl alcohol + NAD(P)+
-
 ?
alditol + NAD(P)+
-
 Homo sapiens aldose + NAD(P)H
-
 r
aldose + NAD(P)H
-
 Homo sapiens alditol + NAD(P)+
-
 r
aldose + NAD(P)H wide specificity Homo sapiens alditol + NAD(P)+
-
 r
benzyl alcohol + oxidized 3-acetylpyridine adenine dinucleotide + H+
-
 Homo sapiens benzaldehyde + reduced 3-acetylpyridine adenine dinucleotide
-
 ?
D-galactose + NAD(P)H
-
 Homo sapiens dulcitol + NAD(P)+
-
 ?
D-glucose + NAD(P)H
-
 Homo sapiens sorbitol + NAD(P)+
-
 r
D-glucuronate + NAD(P)H
-
 Homo sapiens ?
-
 r
DL-glyceraldehyde + NAD(P)H
-
 Homo sapiens glycerol + NAD(P)+
-
 r
succinic semialdehyde + NADH + H+
-
 Homo sapiens 4-hydroxybutyrate + NAD+
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 32000, SDS-PAGE in presence of 2-mercaptoethanol Homo sapiens

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens