Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chrysin | - |
Mus musculus | |
fidarestat | - |
Mus musculus | |
minalrestat | inhibition pattern for AKR1C21, overview | Mus musculus | |
additional information | enzyme-inhibitor complexe modelling, Tyr118 and Phe311 are important residues for inhibitor recognition and orientation in the active site of AKR1C21, overview | Mus musculus | |
myricetin | - |
Mus musculus | |
quercetin | inhibition pattern for AKR1C21, overview | Mus musculus | |
quercitrin | - |
Mus musculus | |
sorbinil | - |
Mus musculus | |
Tolrestat | inhibition pattern for AKR1C21, overview | Mus musculus | |
zopolrestat | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3(17)alpha-hydroxysteroid dehydrogenase | - |
Mus musculus |
AKR1C21 | - |
Mus musculus |
More | AKR1C21 is a member of the aldo-keto reductase superfamily | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000009 | - |
pH 7.4, 25°C | Mus musculus | fidarestat | |
0.00003 | - |
pH 7.4, 25°C | Mus musculus | zopolrestat | |
0.00004 | - |
pH 7.4, 25°C | Mus musculus | Tolrestat | |
0.00007 | - |
pH 7.4, 25°C | Mus musculus | minalrestat | |
0.00015 | - |
pH 7.4, 25°C | Mus musculus | quercitrin | |
0.00091 | - |
pH 7.4, 25°C | Mus musculus | sorbinil | |
0.0022 | - |
pH 7.4, 25°C | Mus musculus | quercetin | |
0.0085 | - |
pH 7.4, 25°C | Mus musculus | chrysin | |
0.029 | - |
pH 7.4, 25°C | Mus musculus | myricetin |