Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | 5 mM, 77% inhibition | Mus musculus | |
5alpha-Androstan-3beta-ol-17-one | 1 mM, 80% inhibition | Mus musculus | |
5alpha-pregnan-3beta-ol-21-one | 1 mM, 66% inhibition | Mus musculus | |
5beta-androstan-3beta-ol-17-one | 1 mM, 91% inhibition | Mus musculus | |
5beta-Pregnan-3beta-ol-20-one | 1 mM, 80% inhibition | Mus musculus | |
Barbital | 100 mM, 11% inhibition | Mus musculus | |
Dienstrol | 1 mM, 22% inhibition | Mus musculus | |
Hexestrol | 1 mM, 77% inhibition | Mus musculus | |
Stilbestrol | 10 mM, 75% inhibition | Mus musculus | |
testosterone | 1 mM, 48% inhibition | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
Epitestosterone | cofactor NADP+ | Mus musculus | |
0.0001 | - |
5beta-androstane-3alpha,17beta-diol | cofactor NADP+ | Mus musculus | |
0.0003 | - |
5beta-androstane-3alpha,17beta-diol | cofactor NADP+ | Mus musculus | |
0.0004 | - |
glycolithocholic acid | cofactor NADP+ | Mus musculus | |
0.0005 | - |
5beta-pregnane-3alpha,20alpha-diol | cofactor NADP+ | Mus musculus | |
0.0007 | - |
5beta-pregnane-3alpha-ol-20-one | cofactor NADP+ | Mus musculus | |
0.004 | - |
NADP+ | - |
Mus musculus | |
0.16 | - |
(R)-1-indanol | cofactor NADP+ | Mus musculus | |
0.26 | - |
NAD+ | - |
Mus musculus | |
0.77 | - |
trans-benzene dihydrodiol | cofactor NADP+ | Mus musculus | |
1.99 | - |
cis-benzene dihydrodiol | cofactor NADP+ | Mus musculus | |
2.23 | - |
cyclohex-2-ene-1-ol | cofactor NADP+ | Mus musculus | |
2.67 | - |
Naphthalene dihydrodiol | cofactor NADP+ | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
gel filtration | Mus musculus |
39000 | - |
1 * 39000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Q-Sepharose, Matrex Red A, HA-Ultrogel, Sephadex G-100, two enzyme preparations DD1 and DD2 with almost identical properties, products of post-translational or post-mortem modification rather than isoenzymes | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.27 | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-1-indanol + NADP+ | 37% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 1-indanone + NADPH | - |
? | |
(S)-1-indanole + NADP+ | 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 1-indanone + NADPH | - |
? | |
1-acenaphthenol + NADP+ | 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 1-acenaphthenone + NADPH | - |
? | |
4-nitrobenzaldehyde + NADPH | 58% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 4-nitrobenzyl alcohol + NADP+ | - |
? | |
5alpha-androstane-3alpha,17beta-diol + NADP+ | 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5alpha-androstane-17beta-ol-3-one + NADPH | - |
? | |
5alpha-pregnan-3alpha,20alpha-diol + NADP+ | 6% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5alpha-pregnan-20alpha-ol-3-one + NADPH | - |
? | |
5alpha-pregnan-3alpha,21-diol-20-one + NADP+ | 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5alpha-pregnan-21alpha-ol-3,20-dione + NADPH | - |
? | |
5alpha-pregnane-21-ol-3,20-dione + NADPH | 75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-pregnane-3alpha,21-diol-20-one + NADP+ | - |
? | |
5alpha-pregnane-3,20-dione + NADPH | 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5alpha-pregnane-3alpha-ol-20-one + NADP+ | - |
? | |
5beta-androstan-17beta-ol-3-one + NADPH | 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-androstan-17beta,3alpha-diol + NADP+ | - |
? | |
5beta-androstane-3,17-dione + NADPH | 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-androstan-3alpha-ol-17-one + NADP+ | - |
? | |
5beta-androstane-3alpha,17beta-diol + NADP+ | 11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-androstane-17beta-ol-3-one + NADPH | - |
? | |
5beta-androstane-3alpha-ol-17-one + NADP+ | 9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-androstane-3,17-dione + NADPH | - |
? | |
5beta-pregnan-3alpha,20alpha-diol + NADP+ | 26% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-pregnan-3-one-20alpha-ol + NADPH | - |
? | |
5beta-pregnan-3alpha-ol-20-one + NADP+ | 19% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-pregnan-3,20-dione + NADPH | - |
? | |
5beta-pregnane-3,20-dione + NADPH + H+ | 21% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 5beta-pregnane-3alpha-ol-20-one + NADP+ | - |
? | |
acenaphthenequinone + NADPH | 44% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | acenaphthenehydroquinone + NADP+ | - |
? | |
androst-4-ene-3,17-dione + NADPH | 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | androst-4-ene-3alpha-ol-17-one + NADP+ | - |
? | |
camphorquinone + NADPH + H+ | 52% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | camphorhydroquinone + NADP+ | - |
? | |
cis-1,2-dihydroxy-3,5-cyclohexadiene + NADP+ | 60% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | catechol + NADPH | - |
? | |
cyclohex-2-ene-1-ol + NADP+ | 9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | cyclohex-2-en-1-one + NADPH | - |
? | |
cyclohexanone + NADPH | 16% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | cyclohexanol + NADP+ | - |
? | |
epitestosterone + NADP+ | 11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | testosterone + NADPH + H+ | - |
? | |
glycolithocholic acid + NADP+ | 56% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | N-[(5beta)-3,24-dioxocholan-24-yl]glycine + NADPH | - |
? | |
naphthalene dihydrodiol + NADP+ | 49% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | naphthacatechol + NADPH | - |
? | |
pyridine-4-ol + NADP+ | 75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene | Mus musculus | 3H-pyridine-4-one + NADPH | - |
? | |
tetrahydrodeoxycorticosterone + NAD+ | - |
Mus musculus | ? | - |
r | |
trans-1,2-dihydroxy-3,5-cyclohexadiene + NADP+ | - |
Mus musculus | catechol + NADPH | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 39000, SDS-PAGE | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 6.8 | 5beta-pregnane-3,20-dione as substrate, cofactor NADPH | Mus musculus |