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Literature summary for 1.1.1.209 extracted from

  • Lau, P.C.K.; Layne, D.S.; Williamson, D.G.
    Comparison of the multiple forms of the soluble 3(17)alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver (1982), J. Biol. Chem., 257, 9450-9456.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
androsterone competitive vs. epitestosterone Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00053
-
Epitestosterone liver isozyme IB Oryctolagus cuniculus
0.00061
-
Epitestosterone kidney isozyme II Oryctolagus cuniculus
0.0012
-
androsterone liver isozyme IC Oryctolagus cuniculus
0.0021 0.0024 Epitestosterone liver isozyme IB, androsterone, kidney, isozyme IB Oryctolagus cuniculus
0.00291
-
Epitestosterone kidney isozyme IB Oryctolagus cuniculus
0.004 0.0047 androsterone kidney isozyme II, liver isozyme IB Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
emale
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Oryctolagus cuniculus
-
liver
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-estradiol + NAD(P)+
-
Oryctolagus cuniculus estrone + NAD(P)H
-
r
17alpha-estradiol 3-glucuronide + NAD(P)+
-
Oryctolagus cuniculus estrone 3-glucuronide + NAD(P)H
-
r
3alpha-hydroxy-5alpha-androstan-17-one + NAD(P)+
-
Oryctolagus cuniculus 5alpha-androstan-3,17-dione + NAD(P)H
-
?
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
Oryctolagus cuniculus 17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H i.e. 5alpha-dihydrotestosterone r
epitestosterone + NAD(P)+
-
Oryctolagus cuniculus androst-4-en-3,17-dione + NAD(P)H + H+
-
r
estrone 3-sulfate + NAD(P)H
-
Oryctolagus cuniculus 17alpha-estradiol 3-sulfate + NAD(P)+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Oryctolagus cuniculus
NADH low activity Oryctolagus cuniculus
NADP+ preferred Oryctolagus cuniculus
NADPH preferred Oryctolagus cuniculus