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Literature summary for 1.1.1.205 extracted from

  • Calise, S.J.; Purich, D.L.; Nguyen, T.; Saleem, D.A.; Krueger, C.; Yin, J.D.; Chan, E.K.
    Rod and ring formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway (2016), J. Cell Sci., 129, 3042-3052.
    View publication on PubMed
Search for more literature for 1.1.1.205

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid
-
 Homo sapiens
ribavirin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Homo sapiens
-
 XMP + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P12268
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
HEP-3B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
 Homo sapiens XMP + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
IMP dehydrogenase
-
 Homo sapiens
IMPDH
-
 Homo sapiens
IMPDH2
-
 Homo sapiens
inosine monophosphate dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADH
-
 Homo sapiens

General Information

General Information Comment Organism
additional information siRNA knockdown of serine hydroxymethyltransferase-2, SHMT2, or dihydrofolate reductase, DHFR, leads to increased rod and ring (RR) formation. IMPDH-containing RR structures can form in mammalian cells Homo sapiens
physiological function inosine monophosphate dehydrogenase (IMPDH), a key enzyme leading to GMP and GTP biosynthesis. Rod and ring (RR) formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway. RR formation is induced by IMPDH inhibitors as well as glutamine deprivation. Because RR assembly occurs when guanine nucleotide biosynthesis is inhibited, and because RRs rapidly disassemble after the addition of guanine nucleotide precursors, RR formation might be an adaptive homeostatic mechanism, allowing IMPDH to sense changes in the one-carbon folate pathway, detailed overview Homo sapiens