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Literature summary for 1.1.1.205 extracted from

  • Park, S.J.; Joo, W.A.; Choi, J.; Lee, S.H.; Kim, C.W.
    Identification and characterization of inosine monophosphate dehydrogenase from Halobacterium salinarum (2004), Proteomics, 4, 3632-3641.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21 (DE3) using a pGEX-KG vector Halobacterium salinarum

Metals/Ions

Metals/Ions Comment Organism Structure
NaCl activity at 2 M NaCl is more than 4fold higher than that in the absence of salt Halobacterium salinarum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Halobacterium salinarum rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides XMP + NADH + H+
-
?
IMP + NAD+ + H2O Halobacterium salinarum NRC 34002 rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides XMP + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Halobacterium salinarum
-
-
-
Halobacterium salinarum NRC 34002
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Halobacterium salinarum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.53
-
pH 8.0, 22°C, in absence of salt, substrate: IMP Halobacterium salinarum
2.41
-
pH 8.0, 22°C, at 2 M NaCl, substrate: IMP Halobacterium salinarum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
Halobacterium salinarum XMP + NADH + H+
-
?
IMP + NAD+ + H2O rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides Halobacterium salinarum XMP + NADH + H+
-
?
IMP + NAD+ + H2O
-
Halobacterium salinarum NRC 34002 XMP + NADH + H+
-
?
IMP + NAD+ + H2O rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides Halobacterium salinarum NRC 34002 XMP + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
IMPDH
-
Halobacterium salinarum
inosine monophosphate dehydrogenase
-
Halobacterium salinarum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Halobacterium salinarum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Halobacterium salinarum

General Information

General Information Comment Organism
physiological function rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides Halobacterium salinarum