Cloned (Comment) | Organism |
---|---|
expression in HeLa cell and CHO cell | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12268 | isoform IMPDH2 | - |
Homo sapiens | P20839 | isoform IMPDH1 | - |
Synonyms | Comment | Organism |
---|---|---|
IMPDH1 | - |
Homo sapiens |
IMPDH2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | isiform IMPDH2 undergoes time-dependent proteolysis with the protease-sensitive region mapping within the catalytic domain. Both IMPDH1 and IMPDH2 proteins show reduced proteolysis with pre-incubation of IMP. The presence of AMP results in significant protection of IMPDH2, via a mechanism involving conformational changes upon nucleotide binding to the Bateman domain without affecting catalytic activity | Homo sapiens |
metabolism | isoform IMPDH1 undergoes time-dependent proteolysis with the protease-sensitive region mapping within the catalytic domain. Both IMPDH1 and IMPDH2 proteins show reduced proteolysis with pre-incubation of IMP. The presence of ATP results in significant protection of IMPDH1, via a mechanism involving conformational changes upon nucleotide binding to the Bateman domain without affecting catalytic activity. Mutation R224P, responsible for retinitis pigmentosa, abolishes ATP binding and nucleotide protection and this correlates with an altered propensity to cluster | Homo sapiens |