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Literature summary for 1.1.1.205 extracted from

  • Park, J.H.; Ahn, S.H.
    IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II (2010), Biochem. Biophys. Res. Commun., 392, 588-592.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus strong association of subunit Imd2 with actively transcribed genes, it is not recruited to nontranscribed regions. Serine 2 C-terminal domain phosphorylation of the elongating RNA polymerase II by Ctk1 kinase is required to recruit Imd2 to actively transcribed genes in vivo Saccharomyces cerevisiae 5634
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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General Information

General Information Comment Organism
physiological function IMPDH is recruited to transcription complex through serine 2 phosphorylation of RNA polymerase II C-terminal domain. Subunit Imd2 genetically interacts with Ctk1 kinase. IMPDH is recruited to elongating RNA polymerase II only when serine 2 of the C-terminal domain is phosphorylated by Ctk1 kinase. Loss of Imd2 has little effect on the association of most elongation factors with RNA polymerase II. In cells lacking Imd2 or all the essential IMPDHs in the presence of minimal guanine, a defect in the association of Ctk1 kinase with the promoter region is seen Saccharomyces cerevisiae